RNA therapeutics in the clinic

被引:54
作者
Curreri, Alexander [1 ,2 ]
Sankholkar, Disha [3 ]
Mitragotri, Samir [1 ,2 ]
Zhao, Zongmin [4 ,5 ]
机构
[1] Harvard Univ, John A Paulson Sch Engn & Appl Sci, Cambridge, MA 02138 USA
[2] Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02138 USA
[3] Lexington High Sch, Lexington, MA USA
[4] Univ Illinois, Coll Pharm, Dept Pharmaceut Sci, Chicago, IL 60612 USA
[5] Univ Illinois, Canc Ctr, Chicago, IL 60612 USA
关键词
antisense oligonucleotide; aptamer; clinical trial; gene therapy; lipid nanoparticle; mRNA; mRNA vaccine; RNA therapeutic; siRNA; FAMILIAL CHYLOMICRONEMIA SYNDROME; MOLECULAR-MECHANISMS; IN-VITRO; DELIVERY; VACCINES; HYPERCHOLESTEROLEMIA; OLIGONUCLEOTIDE; CHALLENGES; SIRNA; VACCINATION;
D O I
10.1002/btm2.10374
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Ribonucleic acid (RNA) therapeutics are being actively researched as a therapeutic modality in preclinical and clinical studies. They have become one of the most ubiquitously known and discussed therapeutics in recent years in part due to the ongoing coronavirus pandemic. Since the first approval in 1998, research on RNA therapeutics has progressed to discovering new therapeutic targets and delivery strategies to enhance their safety and efficacy. Here, we provide an overview of the current clinically relevant RNA therapeutics, mechanistic basis of their function, and strategies to improve their clinical use. We discuss the 17 approved RNA therapeutics and perform an in-depth analysis of the 222 ongoing clinical trials, with an emphasis on their respective mechanisms and disease areas. We also provide perspectives on the challenges for clinical translation of RNA therapeutics and suggest potential strategies to address these challenges.
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页数:19
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