Laryngeal and Esophageal Mucosal Protection Using the Angico Gum Biopolymer in a Mouse Model of Reflux

被引：4

作者：

Araujo Leite Sales, Thiago Meneses ^{[1
]}

Nascimento, Renata Rocha ^{[1
]}

Carmo Neto, Joao Pedro ^{[1
]}

Costa Filho, Humberto Barbosa ^{[1
]}

Paula, Suliana Mesquita ^{[1
]}

Araujo de Sousa, Maria Klayre ^{[1
]}

Nogueira, Kerolayne Melo ^{[1
]}

Dias Junior, Genilson Jose ^{[1
]}

Silva, Durcilene Alves ^{[2
]}

Gomes Soares, Pedro Marcos ^{[1
]}

Rolim Medeiros, Jand Venes ^{[2
]}

Duarte Nicolau, Lucas Antonio ^{[2
]}

Sifrim, Daniel ^{[3
]}

Loiola Ponte Souza, Marcellus Henrique ^{[1
]}

机构：

[1] Univ Fed Ceara, Fortaleza, Ceara, Brazil

[2] Fed Univ Parnaiba Delta, Parnaiba, Brazil

[3] Queen Mary Univ London, London, England

来源：

LARYNGOSCOPE | 2023年 / 133卷 / 01期

关键词：

Larynx; esophagus; angico gum and reflux; LARYNGOPHARYNGEAL REFLUX; ALGINATE SUSPENSION; EXTRACT;

D O I：

10.1002/lary.30093

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Objective: This study aimed to evaluate the in vivo protective effect of the angico gum biopolymer in reducing the inflammatory response and preserving the integrity of the laryngeal and esophageal mucosa. Study Design: Animal study. Methods: A murine surgical model of gastroesophageal reflux disease was accomplished and subsequently treated with angico gum or omeprazole. On days 3 and 7 post surgery, samples of the larynx and esophagus, respectively, were collected to measure the level of inflammation (wet weight and myeloperoxidase activity) and mucosal integrity (transepithelial electrical resistance and mucosal permeability to fluorescein). Results: Angico gum and omeprazole decreased laryngeal inflammation (wet weight and myeloperoxidase activity) and dramatically improved the integrity of the laryngeal mucosa. It also reduced inflammation (decreased wet weight and myeloperoxidase activity) of the esophagus and preserved the barrier function (inferred by assessing the integrity of the mucosa). Conclusion: This study demonstrates the protective effect of angico gum in an experimental gastroesophageal reflux disease model. Angico gum attenuates inflammation and impairment of the mucosal barrier function not only in the larynx but also in the esophagus.

引用

页码：162 / 168

页数：7

共 38 条

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