Stereolithography of ceramic scaffolds for bone tissue regeneration: Influence of hydroxyapatite/silica ratio on mechanical properties

被引：5
作者：
Rstakyan, Viktorya [1 ]
Mkhitaryan, Liana [1 ]
Baghdasaryan, Lilit [1 ]
Ghaltaghchyan, Tsovinar [1 ]
Karabekian, Zaruhi [2 ]
Sevoyan, Gohar [2 ]
Aghayan, Marina [1 ,3 ]
Rodriguez, Miguel A. [4 ]
机构：
[1] Natl Acad Sci Republ Armenia, AB Nalbandyan Inst Chem Phys, P Sevak 5-2, Yerevan 0014, Armenia
[2] Natl Acad Sci Armenia, Orbeli Inst Physiol, Orbeli Bros 22, Yerevan 0028, Armenia
[3] FACT Ind, Oismae Tee 124, EE-13513 Tallinn, Estonia
[4] Inst Ceram & Vidrio CSIC, C Kelsen 5, Madrid 28049, Spain
来源：
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS | 2024年 / 152卷
关键词：
Sintering; Biomaterials; Stereolithography; Hydroxyapatite; Scaffolds; TRICALCIUM PHOSPHATE; SIO2; SRO; ZNO; MGO;
D O I：
10.1016/j.jmbbm.2024.106421
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
In this paper, the results obtained in the development of ceramic resin feedstock for stereolithography are shown. Hydroxyapatite and silica are used as source of ceramic. Hydroxyapatite is extracted from bovine bone, which enhances bioactivity of ceramic scaffold. The influence of hydroxyapatite amount in polymer-based slurry on the viscosity and printability of feedstock is explored. Hydroxyapatite and silica containing scaffolds are successfully obtained by stereolithography. Influence of hydroxyapatite/silica ratio on the bioactivity, biodegradability and mechanical properties of the scaffolds is also studied. It was observed that higher concentrations of hydroxyapatite led to improved mechanical strength of the scuffolds but increased viscosity of the slurry, affecting printability. Cell viability assays and cell visualization experiments indicated that the scaffolds not cause significant cell toxicity.
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页数：7
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