The cellular triumvirate: fibroblasts entangled in the crosstalk between cancer cells and immune cells

被引：2
作者：
Fergatova, Adel [1 ]
Affara, Nesrine I. [1 ]
机构：
[1] Carnegie Mellon Univ Qatar, Doha, Qatar
来源：
FRONTIERS IN IMMUNOLOGY | 2024年 / 14卷
基金：
美国安德鲁·梅隆基金会;
关键词：
fibroblasts; immunosuppression; heterogeneity; reprogramming; cancer-associated fibroblasts; CARCINOMA-ASSOCIATED FIBROBLASTS; TGF-BETA; MESENCHYMAL TRANSITION; T-CELLS; TUMOR MICROENVIRONMENT; UP-REGULATION; IN-VITRO; ACTIVATION; IMMUNOSUPPRESSION; INFILTRATION;
D O I：
10.3389/fimmu.2023.1337333
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
This review article will focus on subpopulations of fibroblasts that get reprogrammed by tumor cells into cancer-associated fibroblasts. Throughout this article, we will discuss the intricate interactions between fibroblasts, immune cells, and tumor cells. Unravelling complex intercellular crosstalk will pave the way for new insights into cellular mechanisms underlying the reprogramming of the local tumor immune microenvironment and propose novel immunotherapy strategies that might have potential in harnessing and modulating immune system responses.
引用
收藏
页数：22
相关论文
共 113 条
  • [1] Fibroblasts in the Tumor Microenvironment: Shield or Spear?
    Alkasalias, Twana
    Moyano-Galceran, Lidia
    Arsenian-Henriksson, Marie
    Lehti, Kaisa
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (05)
  • [2] Inhibition of tumor cell proliferation and motility by fibroblasts is both contact and soluble factor dependent
    Alkasalias, Twana
    Flaberg, Emilie
    Kashuba, Vladimir
    Alexeyenko, Andrey
    Pavlova, Tatiana
    Savchenko, Andrii
    Szekely, Laszlo
    Klein, George
    Guven, Hayrettin
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (48) : 17188 - 17193
  • [3] A G2/M Cell Cycle Block in Transformed Cells by Contact with Normal Neighbours
    Allard, David
    Stoker, Michael
    Gherardi, Ermanno
    [J]. CELL CYCLE, 2003, 2 (05) : 484 - 487
  • [4] Fibroblast heterogeneity and tertiary lymphoid tissues in the kidney
    Arai, Hiroyuki
    Sato, Yuki
    Yanagita, Motoko
    [J]. IMMUNOLOGICAL REVIEWS, 2021, 302 (01) : 196 - 210
  • [5] Invadopodia: clearing the way for cancer cell invasion
    Augoff, Katarzyna
    Hryniewicz-Jankowska, Anita
    Tabola, Renata
    [J]. ANNALS OF TRANSLATIONAL MEDICINE, 2020, 8 (14)
  • [6] Mast cells and mast cell tryptase enhance migration of human lung fibroblasts through protease-activated receptor 2
    Bagher, Mariam
    Larsson-Callerfelt, Anna-Karin
    Rosmark, Oskar
    Hallgren, Oskar
    Bjermer, Leif
    Westergren-Thorsson, Gunilla
    [J]. CELL COMMUNICATION AND SIGNALING, 2018, 16
  • [7] Melanoma-associated fibroblasts modulate NK cell phenotype and antitumor cytotoxicity
    Balsamo, Mirna
    Scordamaglia, Francesca
    Pietra, Gabriella
    Manzini, Claudia
    Cantoni, Claudia
    Boitano, Monica
    Queirolo, Paola
    Vermi, William
    Facchetti, Fabio
    Moretta, Alessandro
    Moretta, Lorenzo
    Mingari, Maria Cristina
    Vitale, Massimo
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (49) : 20847 - 20852
  • [8] Mesenchymal Stem Cells are Recruited and Activated into Carcinoma-Associated Fibroblasts by Prostate Cancer Microenvironment-Derived TGF-1
    Barcellos-de-Souza, Pedro
    Comito, Giuseppina
    Pons-Segura, Coral
    Taddei, Maria Letizia
    Gori, Valentina
    Becherucci, Valentina
    Bambi, Franco
    Margheri, Francesca
    Laurenzana, Anna
    Del Rosso, Mario
    Chiarugi, Paola
    [J]. STEM CELLS, 2016, 34 (10) : 2536 - 2547
  • [9] Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing
    Bartoschek, Michael
    Oskolkov, Nikolay
    Bocci, Matteo
    Lovrot, John
    Larsson, Christer
    Sommarin, Mikael
    Madsen, Chris D.
    Lindgren, David
    Pekar, Gyula
    Karlsson, Goran
    Ringner, Markus
    Bergh, Jonas
    Bjorklund, Asa
    Pietras, Kristian
    [J]. NATURE COMMUNICATIONS, 2018, 9
  • [10] Chemotherapy-induced COX-2 upregulation by cancer cells defines their inflammatory properties and limits the efficacy of chemoimmunotherapy combinations
    Bell, Charlotte R.
    Pelly, Victoria S.
    Moeini, Agrin
    Chiang, Shih-Chieh
    Flanagan, Eimear
    Bromley, Christian P.
    Clark, Christopher
    Earnshaw, Charles H.
    Koufaki, Maria A.
    Bonavita, Eduardo
    Zelenay, Santiago
    [J]. NATURE COMMUNICATIONS, 2022, 13 (01)
12345678910