Genetics in Ischemic Stroke: Current Perspectives and Future Directions

被引：5

作者：

Zhang, Ka ^{[1
]}

Loong, Shaun ^{[2
,3
]}

Yuen, Linus ^{[3
]}

Venketasubramanian, Narayanaswamy ^{[4
]}

Chin, Hui-Lin ^{[5
]}

Lai, Poh San ^{[6
]}

Tan, Benjamin ^{[1
,3
]}

机构：

[1] Natl Univ Singapore Hosp, Dept Med, Div Neurol, Singapore 119074, Singapore

[2] Natl Univ Singapore, Yong Loo Lin Sch Med, Cardiovasc Metab Translat Res Program, Singapore 119077, Singapore

[3] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore 119077, Singapore

[4] Raffles Hosp, Raffles Neurosci Ctr, Singapore 188770, Singapore

[5] Khoo Teck Puat Natl Univ, Childrens Med Inst, Natl Univ Hosp, Singapore 119074, Singapore

[6] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Paediat, Singapore 119077, Singapore

来源：

JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE | 2023年 / 10卷 / 12期

关键词：

genetics; ischemic stroke; stroke recovery; genome-wide association studies (GWASs); pharmacogenetics; pharmacogenomics; SMALL VESSEL DISEASE; GENOME-WIDE ASSOCIATION; ATRIAL-FIBRILLATION; CANDIDATE GENE; RISK; CLOPIDOGREL; LOCI; METAANALYSIS; VARIANT; VKORC1;

D O I：

10.3390/jcdd10120495

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Ischemic stroke is a heterogeneous condition influenced by a combination of genetic and environmental factors. Recent advancements have explored genetics in relation to various aspects of ischemic stroke, including the alteration of individual stroke occurrence risk, modulation of treatment response, and effectiveness of post-stroke functional recovery. This article aims to review the recent findings from genetic studies related to various clinical and molecular aspects of ischemic stroke. The potential clinical applications of these genetic insights in stratifying stroke risk, guiding personalized therapy, and identifying new therapeutic targets are discussed herein.

引用

页数：21

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