Cut-off values of haemoglobin and clinical outcomes in incident peritoneal dialysis: the PDTAP study

被引：6

作者：

Xu, Xiao ^{[1
]}

Yang, Zhikai ^{[1
]}

Li, Shaomei ^{[2
]}

Pei, Huayi ^{[2
]}

Zhao, Jinghong ^{[3
]}

Zhang, Ying ^{[3
]}

Xiong, Zibo ^{[4
]}

Liao, Yumei ^{[4
]}

Li, Ying ^{[5
]}

Lin, Qiongzhen ^{[5
]}

Hu, Wenbo ^{[6
]}

Li, Yulin ^{[6
]}

Zheng, Zhaoxia ^{[7
]}

Duan, Liping ^{[7
]}

Fu, Gang ^{[8
]}

Guo, Shanshan ^{[8
]}

Zhang, Beiru ^{[9
]}

Yu, Rui ^{[9
]}

Sun, Fuyun ^{[10
]}

Ma, Xiaoying ^{[10
]}

Hao, Li ^{[11
]}

Liu, Guiling ^{[11
]}

Zhao, Zhanzheng ^{[12
]}

Xiao, Jing ^{[12
]}

Shen, Yulan ^{[13
]}

Zhang, Yong ^{[13
]}

Du, Xuanyi ^{[14
]}

Ji, Tianrong ^{[14
]}

Wang, Caili ^{[15
]}

Deng, Lirong ^{[15
]}

Yue, Yingli ^{[16
]}

Chen, Shanshan ^{[16
]}

Ma, Zhigang ^{[17
]}

Li, Yingping ^{[17
]}

Zuo, Li ^{[18
]}

Zhao, Huiping ^{[18
]}

Zhang, Xianchao ^{[19
]}

Wang, Xuejian ^{[19
]}

Liu, Yirong ^{[20
]}

Gao, Xinying ^{[20
]}

Chen, Xiaoli ^{[21
]}

Li, Hongyi ^{[21
]}

Du, Shutong ^{[22
]}

Zhao, Cui ^{[22
]}

Xu, Zhonggao ^{[23
]}

Zhang, Li ^{[23
]}

Chen, Hongyu ^{[24
]}

Li, Li ^{[24
]}

Wang, Lihua ^{[25
]}

Yan, Yan ^{[25
]}

机构：

[1] Peking Univ, Inst Nephrol, Key Lab Renal Dis, Renal Div,Dept Med,Hosp 1,Minist Hlth,Key LabRenal, Beijing, Peoples R China

[2] Hebei Med Univ, Dept Med, Renal Div, Hosp 2, Shijiazhuang, Hebei, Peoples R China

[3] Third Mil Med Univ, Army Med Univ, Xinqiao Hosp, Dept Nephrol,Key Lab Prevent & Treatment Chron Kid, Chongqing, Peoples R China

[4] Peking Univ, Shenzhen Hosp, Dept Med, Renal Div, Shenzhen, Guangdong, Peoples R China

[5] Hebei Med Univ, Hosp 3, Dept Med, Renal Div, Shijiazhuang, Hebei, Peoples R China

[6] Peoples Hosp Qinghai Prov, Dept Med, Renal Div, Xining, Qinghai, Peoples R China

[7] Handan Cent Hosp, Dept Med, Renal Div, Handan, Hebei, Peoples R China

[8] Peking Haidian Hosp, Dept Med, Renal Div, Beijing, Peoples R China

[9] China Med Univ, Shengjing Hosp, Dept Nephrol, Shenyang, Liaoning, Peoples R China

[10] Cangzhou Cent Hosp, Dept Med, Renal Div, Cangzhou, Hebei, Peoples R China

[11] Anhui Med Univ, Affiliated Hosp 2, Dept Med, Renal Div, Hefei, Anhui, Peoples R China

[12] Zhengzhou Univ, Dept Med, Renal Div, Affiliated Hosp 1, Zhengzhou, Henan, Peoples R China

[13] Beijing Miyun Dist Hosp, Dept Med, Renal Div, Beijing, Peoples R China

[14] Harbin Med Univ, Affiliated Hosp 2, Dept Med, Renal Div, Harbin, Heilongjiang, Peoples R China

[15] BaoTou Med Coll, Dept Med, Renal Div, Affiliated Hosp 1, Neimenggu, Peoples R China

[16] Peoples Hosp Langfang, Dept Med, Renal Div, Langfang, Hebei, Peoples R China

[17] Peoples Hosp Gansu, Dept Med, Renal Div, Lanzhou, Gansu, Peoples R China

[18] Peking Univ, Dept Med, Renal Div, Peoples Hosp, Beijing, Peoples R China

[19] Pingdingshan First Peoples Hosp, Dept Med, Renal Div, Pingdingshan, Henan, Peoples R China

[20] First Peoples Hosp Xining, Dept Med, Renal Div, Xining, Qinghai, Peoples R China

[21] Taiyuan Cent Hosp, Dept Med, Renal Div, Taiyuan, Shanxi, Peoples R China

[22] Cangzhou Peoples Hosp, Dept Med, Renal Div, Cangzhou, Hebei, Peoples R China

[23] First Hosp Jilin Univ, Dept Med, Renal Div, Changchun, Jilin, Peoples R China

[24] Peoples Hosp Chuxiong Yi Autonomous Prefecture, Dept Med, Renal Div, Chuxiong, Yunnan, Peoples R China

[25] Shanxi Med Univ, Hosp 2, Dept Med, Renal Div, Xian, Shanxi, Peoples R China

[26] Beijing Boai Hosp, China Rehabil Res Ctr, Dept Med, Renal Div, Beijing, Peoples R China

[27] Beijing Dongzhimen Hosp, Dept Med, Renal Div, Beijing, Peoples R China

[28] Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing, Peoples R China

来源：

NEPHROLOGY DIALYSIS TRANSPLANTATION | 2024年 / 39卷 / 02期

关键词：

anaemia; haemoglobin; major adverse cardiovascular events; mortality; peritoneal dialysis; HEMODIALYSIS-PATIENTS; ANEMIA MANAGEMENT; MORTALITY RISK; EPOETIN-ALPHA; ASSOCIATION; DISEASE; PREVENTION; GUIDELINES; COHORT; HEART;

D O I：

10.1093/ndt/gfad166

中图分类号：

R3 [基础医学]; R4 [临床医学];

学科分类号：

1001 ; 1002 ; 100602 ;

摘要：

Background. To explore the cut-off values of haemoglobin (Hb) on adverse clinical outcomes in incident peritoneal dialysis (PD) patients based on a national-level database.Methods. The observational cohort study was from the Peritoneal Dialysis Telemedicine-assisted Platform (PDTAP) dataset. The primary outcomes were all-cause mortality, major adverse cardiovascular events (MACE) and modified MACE (MACE+). The secondary outcomes were the occurrences of hospitalization, first-episode peritonitis and permanent transfer to haemodialysis (HD).Results. A total of 2591 PD patients were enrolled between June 2016 and April 2019 and followed up until December 2020. Baseline and time-averaged Hb <100 g/l were associated with all-cause mortality, MACE, MACE+ and hospitalizations. After multivariable adjustments, only time-averaged Hb <100 g/l significantly predicted a higher risk for all-cause mortality {hazard ratio [HR] 1.83 [95% confidence interval (CI) 1.19-281], P = .006}, MACE [HR 1.99 (95% CI 1.16-3.40), P = .012] and MACE+ [HR 1.77 (95% CI 1.15-2.73), P = .010] in the total cohort. No associations between Hb and hospitalizations, transfer to HD and first-episode peritonitis were observed. Among patients with Hb >= 100 g/l at baseline, younger age, female, use of iron supplementation, lower values of serum albumin and renal Kt/V independently predicted the incidence of Hb <100 g/l during the follow-up.Conclusion. This study provided real-world evidence on the cut-off value of Hb for predicting poorer outcomes through a nation-level prospective PD cohort.

引用

页码：251 / 263

页数：13

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