Clinical significance of neutrophil-to-lymphocyte ratio on the risk of abdominal aortic calcification and decreased bone mineral density in patients with end-stage kidney disease

被引：4

作者：

Ban, Tae Hyun ^{[1
]}

Choi, Bum Soon ^{[1
]}

Yoon, Sun Ae ^{[2
]}

Kim, Yaerim ^{[3
]}

Jin, Kyubok ^{[3
]}

Kim, Gheun-Ho ^{[4
]}

Lee, Young-Ki ^{[5
]}

Oh, Kook-Hwan ^{[6
]}

Lee, Sang-Ho ^{[7
]}

Jung, Ji Yong ^{[8
]}

Park, Hyeong Cheon ^{[9
]}

Ahn, Shin Young ^{[10
]}

Ko, Gang-Jee ^{[10
]}

Kwon, Young Joo ^{[10
]}

Hong, Yu Ah ^{[11
]}

机构：

[1] Catholic Univ Korea, Eunpyeong St Marys Hosp, Coll Med, Dept Internal Med,Div Nephrol, Seoul, South Korea

[2] Catholic Univ Korea, Uijeongbu St Marys Hosp, Coll Med, Dept Internal Med,Div Nephrol, Seoul, South Korea

[3] Keimyung Univ, Sch Med, Dept Internal Med, Div Nephrol, Daegu, South Korea

[4] Hanyang Univ, Coll Med, Dept Internal Med, Div Nephrol, Seoul, South Korea

[5] Hallym Univ, Dept Internal Med, Div Nephrol, Kangnam Sacred Heart Hosp, Seoul, South Korea

[6] Seoul Natl Univ, Coll Med, Dept Internal Med, Div Nephrol, Seoul, South Korea

[7] Kyung Hee Univ, Kyunghee Univ Hosp Gangdong, Coll Med, Dept Internal Med,Div Nephrol, Seoul, South Korea

[8] Gachon Univ, Coll Med, Dept Internal Med, Div Nephrol,Gil Med Ctr, Incheon, South Korea

[9] Yonsei Univ, Gangnam Severance Hosp, Dept Internal Med, Div Nephrol,Coll Med, Seoul, South Korea

[10] Korea Univ, Coll Med, Dept Internal Med, Div Nephrol,Guro Hosp, Seoul, South Korea

[11] Catholic Univ Korea, Daejeon St Marys Hosp, Dept Internal Med, Div Nephrol,Coll Med, Seoul, South Korea

来源：

PLOS ONE | 2023年 / 18卷 / 10期

基金：

新加坡国家研究基金会;

关键词：

RENAL-DISEASE; VASCULAR CALCIFICATION; CARDIOVASCULAR EVENTS; NEUTROPHIL/LYMPHOCYTE RATIO; DIALYSIS PATIENTS; INFLAMMATION; PREDICTOR; ASSOCIATION; PROGRESSION; DISORDER;

D O I：

10.1371/journal.pone.0286612

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Inflammation plays a major role in the pathogenesis of chronic kidney disease (CKD), but the relationship between systemic inflammation and CKD-mineral bone disease is unclear. We aimed to investigate whether the neutrophil-to-lymphocyte ratio (NLR) is related to abdominal aortic calcification (AAC) and bone mineral density (BMD) in dialysis patients. In this cross-sectional analysis using baseline data of a multicenter cohort, a total of 759 patients were divided into three groups according to NLR level, and the associations between NLR and Kauppila AAC score (AACS) and BMD were assessed. The highest tertile NLR group had more males, alcohol consumers, higher diabetes prevalence, and higher comorbidity index than the lowest tertile NLR group. Fasting glucose and C-reactive protein levels were higher, while serum albumin, serum iron, and lipid profiles except triglycerides were lower in the highest tertile group. AACS was significantly higher in the highest tertile group than in the lowest and middle tertile groups (p = 0.017), but the mean areal BMD and T-score of the lumbar spine and femur were not different between groups. NLR level was positively correlated with AACS in all aortic wall segments except L1 and L3 anterior. In multivariable logistic regression analysis, the highest tertile NLR group was independently associated with AAC (odds ratio 2.876, 95% confidence interval 1.250-6.619, p = 0.013) but was not associated with osteoporosis in the lumbar spine and femur after adjusting for confounding factors. The NLR can be used as a potential indicator of AAC in dialysis patients.

引用

页数：15

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[41] Abdominal aortic calcific deposits are an important predictor of vascular morbidity and mortality [J].