Effect of probiotics and fecal microbiota transplantation in dirty rats with established primary liver cancer

被引：3
作者：
Cao, Yanyan [1 ,2 ]
Zhang, Lijie [1 ,2 ]
Xiong, Fu [1 ,2 ]
Guo, Xiaopeng [1 ,2 ]
Kan, Xuefeng [1 ,2 ]
Song, Songlin [1 ,2 ]
Liang, Bo [1 ,2 ]
Liang, Bin [1 ,2 ]
Yu, Li [3 ]
Zheng, Chuansheng [1 ,2 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Radiol, Wuhan 430022, Hubei, Peoples R China
[2] Hubei Prov Key Lab Mol Imaging, Wuhan 430022, Hubei, Peoples R China
[3] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Emergency Med, Wuhan 430022, Hubei, Peoples R China
来源：
FUTURE MICROBIOLOGY | 2024年 / 19卷 / 02期
关键词：
dirty rat; fecal microbiota transplantation; liver cancer; microbiota; probiotics; HEPATOCELLULAR-CARCINOMA; GUT MICROBIOTA; HEALTH;
D O I：
10.2217/fmb-2022-0234
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Background: The modulating effects of probiotics and fecal microbiota transplantation (FMT) on gut flora and their direct antitumor effects remain unclear in dirty rats with established primary liver cancer. Materials & methods: Probiotics (VSL#3), FMT or tap water were administrated to three groups. Fresh fecal samples were collected from all groups for 16S rRNA analysis. Liver cancer tissues were collected to evaluate the tumor response. Results: Significant modulation of beta-diversity (p = 0.023) was observed after FMT. VSL#3 and FMT had no inhibitory effect on tumors, but the density of Treg cells decreased (p = 0.031) in the FMT group. Conclusion: FMT is a more attractive alternative to probiotics in dirty rats with liver cancer.
引用
收藏
页码：117 / 129
页数：13
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