Health-related quality of life after surviving intensive care for COVID-19: a prospective multicenter cohort study

被引:6
作者
Halvorsen, Peter [1 ,12 ]
Hultstroem, Michael [1 ,2 ]
Haestbacka, Johanna [3 ,4 ,5 ,6 ]
Larsson, Ing-Marie [1 ]
Eklund, Rakel [7 ]
Arnberg, Filip K. [7 ]
Hokkanen, Laura [8 ]
Frithiof, Robert [1 ]
Wallin, Ewa [1 ]
Orwelius, Lotti [9 ,10 ]
Lipcsey, Miklos [1 ,11 ]
机构
[1] Uppsala Univ, Dept Surg Sci, Anesthesiol & Intens Care Med, Uppsala, Sweden
[2] Uppsala Univ, Dept Med Cell Biol, Integrat Physiol, Uppsala, Sweden
[3] Helsinki Univ Hosp, Dept Perioperat Intens Care & Pain Med, Helsinki, Finland
[4] Univ Helsinki, Helsinki, Finland
[5] Tampere Univ Hosp, Dept Anesthesiol & Intens Care, Tampere, Finland
[6] Tampere Univ, Tampere, Finland
[7] Uppsala Univ, Natl Ctr Disaster Psychiat, Dept Med Sci, Uppsala, Sweden
[8] Univ Helsinki, Fac Med, Dept Psychol & Logoped, Helsinki, Finland
[9] Linkoping Univ Hosp, Dept Intens Care, Linkoping, Sweden
[10] Linkoping Univ, Biomed & Clin Sci, Linkoping, Sweden
[11] Uppsala Univ, Dept Surg Sci, Hedenstierna Lab, Uppsala, Sweden
[12] Uppsala Univ, Dept Anesthes & Intens Care, Akad Sjukhuset, Ing 70, S-75185 Uppsala, Sweden
基金
瑞典研究理事会;
关键词
MORTALITY; SF-36;
D O I
10.1038/s41598-023-45346-2
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
In survivors of severe coronavirus disease 2019 (COVID-19) incomplete mental and physical recovery may considerably impact daily activities and health-related quality of life (HRQoL). HRQoL can be evaluated with the RAND-36 questionnaire, a multidimensional instrument that assesses physical and mental aspects of health in eight dimensions. The objective was to investigate HRQoL in intensive care patients previously treated for COVID-19 at three Nordic university hospitals, in a prospective multi-center cohort study. HRQoL was measured using RAND-36, 3-9 months after discharge from intensive care units (ICU). One hospital performed a second follow-up 12 months after discharge. A score under the lower limit of the 95% confidence interval in the reference cohorts was considered as significantly reduced HRQoL. We screened 542 and included 252 patients. There was more than twice as many male (174) as female (78) patients and the median age was 61 (interquartile range, IQR 52-69) years. Hypertension was the most common comorbidity observed in 132 (52%) patients and 121 (48%) patients were mechanically ventilated for a median of 8 (IQR 4-14) days. In RAND-36 physical functioning, physical role functioning, general health (p < 0.001 for all) and social functioning (p < 0.05) were below reference, whereas bodily pain, emotional role functioning and mental health were not. In a time-to-event analysis female sex was associated with a decreased chance of reaching the reference HRQoL in the physical function, bodily pain and mental health dimensions. Higher body mass index was found in the physical functioning dimension and hypertension in the physical functioning, vitality and social functioning dimensions. Similar results were seen for diabetes mellitus in general health, vitality and mental health dimensions, as well as pulmonary illness in the physical role functioning dimension and psychiatric diagnosis in the social functioning dimension. Mechanical ventilation was associated with a decreased likelihood of achieving reference HRQoL in the bodily pain and physical functioning dimensions. Patients treated in an ICU because of COVID-19 had lower HRQoL 3-9 months after ICU discharge than 95% of the general population. Physical dimensions were more severely affected than mental dimensions. Female sex and several comorbidities were associated with a slower rate of recovery.Study registration: clinicaltrials.gov: NCT04316884 registered on the 13th of March 2020, NCT04474249 registered on the 29th of June 2020 and NCT04864938 registered on the 4th of April 2021.
引用
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页数:9
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共 39 条
  • [21] Poor long-term recovery after critical COVID-19 during 12 months longitudinal follow-up
    Larsson, Ing-Marie
    Hultstrom, Michael
    Lipcsey, Miklos
    Frithiof, Robert
    Rubertsson, Sten
    Wallin, Ewa
    [J]. INTENSIVE AND CRITICAL CARE NURSING, 2023, 74
  • [22] Women report more symptoms and impaired quality of life: a survey of Finnish COVID-19 survivors
    Lindahl, Anna
    Aro, Miia
    Reijula, Jere
    Makela, Mika J.
    Ollgren, Jukka
    Puolanne, Mervi
    Jarvinen, Asko
    Vasankari, Tuula
    [J]. INFECTIOUS DISEASES, 2022, 54 (01) : 53 - 62
  • [23] Respiratory rehabilitation in elderly patients with COVID-19: A randomized controlled study
    Liu, Kai
    Zhang, Weitong
    Yang, Yadong
    Zhang, Jinpeng
    Li, Yunqian
    Chen, Ying
    [J]. COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE, 2020, 39
  • [24] Post-acute COVID-19 syndrome (PCS) and health-related quality of life (HRQoL)-A systematic review and meta-analysis
    Malik, Preeti
    Patel, Karan
    Pinto, Candida
    Jaiswal, Richa
    Tirupathi, Raghavendra
    Pillai, Shreejith
    Patel, Urvish
    [J]. JOURNAL OF MEDICAL VIROLOGY, 2022, 94 (01) : 253 - 262
  • [25] Clinical and psychological correlates of health-related quality of life in obese patients
    Mannucci, Edoardo
    Petroni, Maria L.
    Villanova, Nicola
    Rotella, Carlo M.
    Apolone, Giovanni
    Marchesini, Giulio
    [J]. HEALTH AND QUALITY OF LIFE OUTCOMES, 2010, 8
  • [26] Quality of Life (QoL) Is Reduced in Those with Severe COVID-19 Disease, Post-Acute Sequelae of COVID-19, and Hospitalization in United States Adults from Northern Colorado
    McFann, Kim
    Baxter, Bridget A.
    LaVergne, Stephanie M.
    Stromberg, Sophia
    Berry, Kailey
    Tipton, Madison
    Haberman, Jared
    Ladd, Jeremy
    Webb, Tracy L.
    Dunn, Julie A.
    Ryan, Elizabeth P.
    [J]. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2021, 18 (21)
  • [27] Incidence and risk factors for persistent symptoms in adults previously hospitalized for COVID-19
    Munblit, Daniel
    Bobkova, Polina
    Spiridonova, Ekaterina
    Shikhaleva, Anastasia
    Gamirova, Aysylu
    Blyuss, Oleg
    Nekliudov, Nikita
    Bugaeva, Polina
    Andreeva, Margarita
    DunnGalvin, Audrey
    Comberiati, Pasquale
    Apfelbacher, Christian
    Genuneit, Jon
    Avdeev, Sergey
    Kapustina, Valentina
    Guekht, Alla
    Fomin, Victor
    Svistunov, Andrey A.
    Timashev, Peter
    Subbot, Vladislav S.
    Royuk, Valery V.
    Drake, Thomas M.
    Hanson, Sarah Wulf
    Merson, Laura
    Carson, Gail
    Horby, Peter
    Sigfrid, Louise
    Scott, Janet T.
    Semple, Malcolm G.
    Warner, John O.
    Vos, Theo
    Olliaro, Piero
    Glybochko, Petr
    Butnaru, Denis
    [J]. CLINICAL AND EXPERIMENTAL ALLERGY, 2021, 51 (09) : 1107 - 1120
  • [28] The Swedish RAND-36: psychometric characteristics and reference data from the Mid-Swed Health Survey
    Ohlsson-Nevo, Emma
    Hiyoshi, Ayako
    Noren, Paulina
    Moller, Margareta
    Karlsson, Jan
    [J]. JOURNAL OF PATIENT-REPORTED OUTCOMES, 2021, 5 (01)
  • [29] Characteristics and influence on quality of life of new-onset pain in critical COVID-19 survivors
    Ojeda, Antonio
    Calvo, Andrea
    Cunat, Tomas
    Mellado-Artigas, Ricard
    Comino-Trinidad, Oscar
    Aliaga, Jorge
    Arias, Marilyn
    Ferrando, Carlos
    Martinez-Palli, Graciela
    Dursteler, Christian
    [J]. EUROPEAN JOURNAL OF PAIN, 2022, 26 (03) : 680 - 694
  • [30] The swedish rand-36 health survey-reliability and responsiveness assessed in patient populations using svensson’s method for paired ordinal data
    Orwelius L.
    Nilsson M.
    Nilsson E.
    Wenemark M.
    Walfridsson U.
    Lundström M.
    Taft C.
    Palaszewski B.
    Kristenson M.
    [J]. Journal of Patient-Reported Outcomes, 2 (1)