Recent developments in frailty identification, management, risk factors and prevention: A narrative review of leading journals in geriatrics and gerontology

被引:62
作者
Dent, Elsa [1 ]
Hanlon, Peter [2 ]
Sim, Marc [3 ,4 ]
Jylhava, Juulia [5 ,6 ,7 ]
Liu, Zuyun [8 ,9 ]
Vetrano, Davide L. [10 ,11 ,12 ]
Stolz, Erwin [13 ]
Perez-Zepeda, Mario Ulises [14 ,15 ]
Crabtree, Daniel R. [16 ]
Nicholson, Caroline [17 ]
Job, Jenny [17 ]
Ambagtsheer, Rachel C. [1 ]
Ward, Paul R. [1 ]
Shi, Sandra M. [18 ,19 ]
Huynh, Quan [20 ]
Hoogendijk, Emiel O. [21 ,22 ,23 ]
机构
[1] Torrens Univ Australia, Res Ctr Publ Hlth Equ & Human Flourishing, Adelaide, SA, Australia
[2] Univ Glasgow, Sch Hlth & Wellbeing, Glasgow, Lanark, Scotland
[3] Edith Cowan Univ, Nutr & Hlth Innovat Res Inst, Sch Hlth & Med Sci, Perth, WA, Australia
[4] Univ Western Australia, Sch Med, Perth, WA, Australia
[5] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
[6] Univ Tampere, Unit Hlth Sci, Fac Social Sci, Tampere, Finland
[7] Univ Tampere, Gerontol Res Ctr, Tampere, Finland
[8] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Hangzhou 310058, Zhejiang, Peoples R China
[9] Zhejiang Univ, Sch Publ Hlth, Sch Med, Key Lab Intelligent Prevent Med Zhejiang Prov, Hangzhou 310058, Zhejiang, Peoples R China
[10] Karolinska Inst, Dept Neurobiol Care Sci & Soc, Aging Res Ctr, Stockholm, Sweden
[11] Stockholm Univ, Stockholm, Sweden
[12] Stockholm Gerontol Res Ctr, Stockholm, Sweden
[13] Med Univ Graz, Inst Social Med & Epidemiol, Graz, Austria
[14] Inst Nacl Geriatria, Direcc Invest, Mexico City, DF, Mexico
[15] Univ Anahuac Mexico, FCS, Ctr Invest Ciencias Salud CICSA, Campus Norte, Huixquilucan, Edo De Mexico, Mexico
[16] Univ Aberdeen, Rowett Inst, Aberdeen AB25 2ZD, Scotland
[17] Univ Queensland, Ctr Hlth Syst Reform & Integrat, Mater Res Inst, Brisbane, Qld, Australia
[18] Hebrew Senior Life, Hinda & Arthur Marcus Inst Aging, Boston, MA USA
[19] Harvard Med Sch, Dept Med, Beth Israel Deaconess Med Ctr, Boston, MA USA
[20] Baker Heart & Diabet Inst, Melbourne, Vic, Australia
[21] Locat VU Univ Med Ctr, Amsterdam UMC, Dept Epidemiol & Data Sci, Amsterdam, Netherlands
[22] Locat VU Univ Med Ctr, Amsterdam UMC, Dept Gen Practice, Amsterdam, Netherlands
[23] Amsterdam UMC, Ageing & Later Life Res Program, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands
基金
英国医学研究理事会; 芬兰科学院;
关键词
Frailty; Aged; Biomarkers; Risk Factors; Geriatric Assessment; OLDER-ADULTS; PRE-FRAIL; ALCOHOL-CONSUMPTION; PHYSICAL FRAILTY; MUSCLE FUNCTION; CARE; HEALTH; PEOPLE; COHORT; METAANALYSIS;
D O I
10.1016/j.arr.2023.102082
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Frailty is an age-related clinical condition characterised by an increased susceptibility to stressors and an elevated risk of adverse outcomes such as mortality. In the light of global population ageing, the prevalence of frailty is expected to soar in coming decades. This narrative review provides critical insights into recent developments and emerging practices in frailty research regarding identification, management, risk factors, and prevention. We searched journals in the top two quartiles of geriatrics and gerontology (from Clarivate Journal Citation Reports) for articles published between 01 January 2018 and 20 December 2022. Several recent developments were identified, including new biomarkers and biomarker panels for frailty screening and diagnosis, using artificial intelligence to identify frailty, and investigating the altered response to medications by older adults with frailty. Other areas with novel developments included exercise (including technology-based exercise), multidimensional interventions, person-centred and integrated care, assistive technologies, analysis of frailty transitions, risk-factors, clinical guidelines, COVID-19, and potential future treatments. This review identified a strong need for the implementation and evaluation of cost-effective, community-based interventions to manage and prevent frailty. Our findings highlight the need to better identify and support older adults with frailty and involve those with frailty in shared decision-making regarding their care.
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页数:15
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