A perylenemonoimide-based fluorescent probe: ultrasensitive and selective tracing of endogenous peroxynitrite in living cells

被引：0
|
作者：
Khan, Aasif [1 ]
Meena, Vinod Kumar [1 ]
Silswal, Akshay [1 ]
Koner, Apurba Lal [1 ]
机构：
[1] Indian Inst Sci Educ & Res Bhopal, Dept Chem, Bionanotechnol Lab, Bhopal Bypass Rd, Bhopal, Madhya Pradesh, India
来源：
ANALYST | 2023年 / 148卷 / 23期
关键词：
OXIDATION;
D O I：
10.1039/d3an01469j
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Peroxynitrite (ONOO-), a highly reactive species, plays a key role in various physiological and pathological processes. Herein, a red-emitting fluorescent reporter perylenemonoimide-boronate ester (PMI-BE) was synthesized and utilized for ultrasensitive detection of ONOO-. The unique feature of PMI-BE is its nanomolar sensitivity with high selectivity towards ONOO-. Moreover, PMI-BE also detects endogenously generated ONOO- in live cells. Red-emitting PMI-BE was synthesized for ultrasensitive nanomolar detection of peroxynitrite. PMI-BE also responds to endogenously generated peroxynitrite in live macrophase cells.
引用
收藏
页码：5851 / 5855
页数：5
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