DNA methylation profiling and integrative multi-omics analysis of skin samples reveal important contribution of epigenetics and immune response in the pathogenesis of acne vulgaris

被引：2

作者：

Liu, Lin ^{[1
]}

Xue, Yuzhou ^{[2
,3
]}

Chen, Jiayi ^{[1
]}

Li, Yuxin ^{[1
]}

Chen, Tingqiao ^{[1
]}

Pan, Xingyu ^{[1
]}

Zhong, Judan ^{[1
]}

Shao, Xinyi ^{[1
]}

Chen, Yangmei ^{[1
,4
]}

Chen, Jin ^{[1
,4
]}

机构：

[1] Chongqing Med Univ, Affiliated Hosp 1, Dept Dermatol, Chongqing, Peoples R China

[2] Peking Univ Third Hosp, Dept Cardiol, Beijing, Peoples R China

[3] Peking Univ Third Hosp, Inst Vasc Med, Beijing, Peoples R China

[4] Chongqing Med Univ, Affiliated Hosp 1, Dept Dermatol, 1 Youyi Rd, Chongqing 400016, Peoples R China

来源：

CLINICAL IMMUNOLOGY | 2023年 / 255卷

基金：

中国国家自然科学基金;

关键词：

Acne vulgaris; DNA methylation; Integrative multi-omics analysis; Multi-omics; PATTERNS; DISEASE;

D O I：

10.1016/j.clim.2023.109773

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The regulatory effect of DNA methylation on the pathogenesis of acne vulgaris is completely unknown. Herein we analyzed the DNA methylation profile in skin samples of acne vulgaris and further integrated it with gene expression profiles and single-cell RNA-sequencing data. Finally, 31,134 differentially methylated sites and 770 differentially methylated and expressed genes (DMEGs) were identified. The multi-omics analysis suggested the importance of DNA methylation in inflammation and immunity in acne. And DMEGs were verified in an external dataset and were closely related to early inflammatory acne. Additionally, we conducted experiments to verify the mRNA expression and DNA methylation level of DMEGs. This study supports the significant contribution of epigenetics to the pathogenesis of acne vulgaris and may provide new ideas for the molecular mechanisms of and potential therapeutic strategies for acne vulgaris.

引用

页数：14

共 5 条

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