Radiation Management for Breast Cancer After Neoadjuvant Therapy

被引：1

作者：

Facer, Benjin D. ^{[1
]}

Wang, Ton ^{[2
]}

Weed, Christina ^{[2
]}

Pariser, Ashley ^{[3
]}

Cherian, Mathew ^{[3
]}

Johnson, Kai C. ^{[3
]}

Quiroga, Dionisia ^{[3
]}

Stover, Daniel ^{[3
]}

Obeng-Gyasi, Samilia ^{[4
]}

Agnese, Doreen ^{[4
]}

Oppong, Bridget A. ^{[4
]}

Goyal, Sharad ^{[5
]}

Andraos, Therese ^{[1
]}

Beyer, Sasha ^{[1
]}

Jhawar, Sachin R. ^{[1
]}

机构：

[1] Ohio State Univ, Dept Radiat Oncol, James Canc Ctr, 460 10th Ave, Columbus, OH 43210 USA

[2] Cedars Sinai Med Ctr, Dept Surg, Div Surg Oncol, 310 North San Vicente Blvd, Los Angeles, CA 90048 USA

[3] Ohio State Univ, Comprehens Canc Ctr, James Canc Hosp, Dept Internal Med,Div Med Oncol, 460 West 10th Ave, Columbus, OH 43210 USA

[4] Ohio State Univ, James Canc Ctr, Dept Surg, Div Surg Oncol, 460 10th Ave, Columbus, OH 43210 USA

[5] George Washington Med Fac Associates, Dept Radiol, Div Radiat Oncol, 2150 Penn Ave NW Level, Washington, DC 20037 USA

来源：

CURRENT BREAST CANCER REPORTS | 2023年 / 15卷 / 04期

关键词：

Neoadjuvant chemotherapy; Breast cancer; Radiation; Regional nodal irradiation; Radiation omission; SURGICAL ADJUVANT BREAST; PREOPERATIVE CHEMOTHERAPY; CONSERVATIVE TREATMENT; SYSTEMIC THERAPY; FOLLOW-UP; CAPECITABINE; RADIOTHERAPY; IRRADIATION; MASTECTOMY; SURVIVAL;

D O I：

10.1007/s12609-023-00506-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose of ReviewNeoadjuvant chemotherapy (NAC) utilization is an important part of breast cancer therapy. Recent advances call into question the optimal role of radiotherapy after NAC, as many radiation studies were performed without NAC. This review was conducted to understand the current data, outstanding questions and ongoing trials related to radiotherapy after NAC.Recent FindingsResponse to NAC is associated with promising clinical outcomes, particularly in triple-negative and HER2+ breast cancer. Retrospective data suggest that modification of radiotherapy based on tumor response to NAC may be appropriate, though caution is advised without prospective randomized evidence. NSABP B-51 and Alliance A011202 will investigate the management of nodal disease in this setting. Future trials will examine the optimal sequencing of treatments.SummaryThe personalization of adjuvant radiotherapy based on response to neoadjuvant chemotherapy is an attractive goal that is currently being evaluated in multiple clinical trials, including NSABP B-51.

引用

页码：371 / 378

页数：8

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