HNF4a in Hepatocyte Health and Disease

被引：11

作者：

Kotulkar, Manasi ^{[1
]}

Robarts, Dakota R. ^{[1
]}

Apte, Udayan ^{[1
,2
]}

机构：

[1] Univ Kansas, Dept Pharmacol Toxicol & Therapeut, Med Ctr, Kansas City, KS USA

[2] Univ Kansas, Dept Pharmacol Toxicol & Therapeut, Med Ctr, 3901 Rainbow Blvd,MS1018, Kansas City, KS 66160 USA

来源：

SEMINARS IN LIVER DISEASE | 2023年 / 43卷 / 02期

关键词：

hepatocyte nuclear factor 4 & alpha; liver development; hepatocyte differentiation; therapeutic target; NUCLEAR FACTOR 4-ALPHA; TRANSCRIPTION FACTOR HNF-4; HEPATOCELLULAR-CARCINOMA; LIVER DEVELOPMENT; PERFLUOROOCTANOIC ACID; CENTRAL REGULATOR; GENE-EXPRESSION; MESSENGER-RNA; HNF4-ALPHA; FACTOR-4-ALPHA;

D O I：

10.1055/a-2097-0660

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Hepatocyte nuclear factor 4 a (HNF4a) is a highly conserved member of the nuclear receptor superfamily expressed at high levels in the liver, kidney, pancreas, and gut. In the liver, HNF4a is exclusively expressed in hepatocytes, where it is indispensable for embryonic and postnatal liver development and for normal liver function in adults. It is considered a master regulator of hepatic differentiation because it regulates a significant number of genes involved in hepatocyte-specific functions. Loss of HNF4a expression and function is associated with the progression of chronic liver disease. Further, HNF4a is a target of chemical-induced liver injury. In this review, we discuss the role of HNF4a in liver pathophysiology and highlight its potential use as a therapeutic target for liver diseases.

引用

页码：234 / 243

页数：10

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