Biomarkers of aging

被引：156

作者：

Bao, Hainan ^{[2
,3
]}

Cao, Jiani ^{[4
]}

Chen, Mengting ^{[5
,6
,7
]}

Chen, Min ^{[8
,9
,10
]}

Chen, Wei ^{[11
]}

Chen, Xiao ^{[12
]}

Chen, Yanhao ^{[13
]}

Chen, Yu ^{[14
]}

Chen, Yutian ^{[15
]}

Chen, Zhiyang ^{[16
]}

Chhetri, Jagadish K. ^{[17
]}

Ding, Yingjie ^{[2
,3
,18
]}

Feng, Junlin ^{[19
]}

Guo, Jun ^{[20
]}

Guo, Mengmeng ^{[21
]}

He, Chuting ^{[18
,22
,23
,24
]}

Jia, Yujuan ^{[25
]}

Jiang, Haiping ^{[4
,18
,23
,24
]}

Jing, Ying ^{[26
,27
,28
,29
]}

Li, Dingfeng ^{[30
]}

Li, Jiaming ^{[2
,3
,18
]}

Li, Jingyi ^{[18
,22
,23
,24
]}

Liang, Qinhao ^{[31
]}

Liang, Rui ^{[32
]}

Liu, Feng ^{[33
,80
]}

Liu, Xiaoqian ^{[4
,18
,23
,24
]}

Liu, Zuojun ^{[34
]}

Luo, Oscar Junhong ^{[35
]}

Lv, Jianwei ^{[36
]}

Ma, Jingyi ^{[37
]}

Mao, Kehang ^{[38
]}

Nie, Jiawei ^{[39
]}

Qiao, Xinhua ^{[40
]}

Sun, Xinpei ^{[41
]}

Tang, Xiaoqiang ^{[42
]}

Wang, Jianfang ^{[43
]}

Wang, Qiaoran ^{[2
,3
,18
]}

Wang, Siyuan ^{[44
]}

Wang, Xuan ^{[45
]}

Wang, Yaning ^{[46
,47
]}

Wang, Yuhan ^{[18
,22
,23
,24
]}

Wu, Rimo ^{[48
]}

Xia, Kai ^{[49
,50
]}

Xiao, Fu-Hui ^{[51
,52
]}

Xu, Lingyan ^{[53
,54
]}

Xu, Yingying ^{[2
,3
]}

Yan, Haoteng ^{[26
,27
,28
,29
]}

Yang, Liang ^{[55
,56
,57
]}

Yang, Ruici ^{[58
]}

Yang, Yuanxin ^{[59
]}

机构：

[1] Aging Biomarker Consortium ABC, Beijing 100101, Peoples R China

[2] Chinese Acad Sci, Beijing Inst Genom, CAS Key Lab Genom & Precis Med, Beijing 100101, Peoples R China

[3] China Natl Ctr Bioinformat, Beijing 100101, Peoples R China

[4] Chinese Acad Sci, Inst Zool, State Key Lab Stem Cell & Reprod Biol, Beijing 100101, Peoples R China

[5] Cent South Univ, Xiangya Hosp, Dept Dermatol, Changsha 410008, Peoples R China

[6] Cent South Univ, Xiangya Hosp, Hunan Key Lab Aging Biol, Changsha 410008, Peoples R China

[7] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Peoples R China

[8] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Clin Ctr Human Gene Res, Wuhan 430022, Peoples R China

[9] Huazhong Univ Sci & Technol, Hubei Clin Res Ctr Metab & Cardiovasc Dis, Wuhan 430022, Peoples R China

[10] Huazhong Univ Sci & Technol, Hubei Key Lab Metab Abnormal & Vasc Aging, Wuhan 430022, Peoples R China

[11] Tongji Univ, Tongji Hosp, Stem Cell Translat Res Ctr, Sch Med, Shanghai 200065, Peoples R China

[12] Third Mil Med Univ, Daping Hosp, Dept Nucl Med, Chongqing 400042, Peoples R China

[13] Univ Chinese Acad Sci, Shanghai Inst Nutr & Hlth, Chinese Acad Sci, CAS Key Lab Nutr Metab & Food Safety, Shanghai 200031, Peoples R China

[14] Tongji Univ, Clin & Translat Res Ctr Shanghai Matern & Infant, Shanghai Key Lab Maternal Fetal Med,Sch Life Sci, Frontier Sci Ctr Stem Cell Res,Shanghai Key Lab S, Shanghai 200092, Peoples R China

[15] Zhengzhou Univ, Dept Endovasc Surg, Affiliated Hosp 1, Zhengzhou 450052, Peoples R China

[16] Jinan Univ, Inst Ageing & Regenerat Med, Key Lab Regenerat Med, Minist Educ, Guangzhou 510632, Peoples R China

[17] Capital Med Univ, Xuanwu Hosp, Natl Clin Res Ctr Geriatr Dis, Beijing 100053, Peoples R China

[18] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[19] Chinese Acad Sci, Shanghai Inst Nutr & Hlth, CAS Key Lab Tissue Microenvironm & Tumor, Shanghai 200031, Peoples R China

[20] Chinese Acad Med Sci, Beijing Inst Geriatr, Inst Geriatr Med,Key Lab Geriatr, Beijing Hosp,Natl Ctr Gerontol Natl Hlth Commiss, Beijing 100730, Peoples R China

[21] Tsinghua Univ, Sch Pharmaceut Sci, Beijing 100084, Peoples R China

[22] Chinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, Beijing 100101, Peoples R China

[23] Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100101, Peoples R China

[24] Beijing Inst Stem Cell & Regenerat Med, Beijing 100101, Peoples R China

[25] Shanxi Med Univ, Affiliated Hosp 1, Dept Neurol, Taiyuan 030001, Peoples R China

[26] Capital Med Univ, Beijing Municipal Geriatr Med Res Ctr, Xuanwu Hosp, Beijing 100053, Peoples R China

[27] Capital Med Univ, Xuanwu Hosp, Aging Translat Med Ctr, Int Ctr Aging & Canc, Beijing 100053, Peoples R China

[28] Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Xuanwu Hosp, Beijing 100053, Peoples R China

[29] Capital Med Univ, Natl Clin Res Ctr Geriatr Disorders, Xuanwu Hosp, Beijing 100053, Peoples R China

[30] Univ Sci & Technol China, Affiliated Hosp USTC 1, Div Life Sci & Med, Dep Neurol, Hefei 230036, Peoples R China

[31] Wuhan Univ, TaiKang Ctr Life & Med Sci, Coll Life Sci, Wuhan 430072, Peoples R China

[32] Nankai Univ, Tianjin Cent Hosp 1, NHC Key Lab Crit Care Med, Organ Transplant Ctr,Res Inst Transplant Med, Tianjin 300384, Peoples R China

[33] Sun Yat Sen Univ, Guangzhou Key Lab Healthy Aging Res, MOE Key Lab Gene Funct & Regulat, Sch Life Sci,Inst Hlth Aging Res, Guangzhou 510275, Peoples R China

[34] Hainan Univ, Sch Life Sci, Haikou 570228, Hainan, Peoples R China

[35] Jinan Univ, Sch Med, Dept Syst Biomed Sci, Guangzhou 510632, Peoples R China

[36] Xiamen Univ, Sch Life Sci, Xiamen 361102, Peoples R China

[37] Southern Med Univ, Nanfang Hosp, State Key Lab Organ Failure Res, Natl Clin Res Ctr Kidney Dis,Div Nephrol, Guangzhou 510515, Peoples R China

[38] Peking Univ, Acad Adv Interdisciplinary Studies, Peking Tsinghua Ctr Life Sci, Ctr Quantitat Biol CQB, Beijing 100871, Peoples R China

[39] Shanghai Jiao Tong Univ, Int Ctr Aging & Canc,Shanghai Inst Hematol,Collab, State Key Lab Med Gen,Natl Res Ctr Translat Med S, Collaborat Innovat Ctr Hematol,Ruijin Hosp,Sch Me, Shanghai 200025, Peoples R China

[40] Chinese Acad Sci, Inst Biophys, CAS Ctr Excellence Biomacromol, Natl Lab Biomacromol, Beijing 100101, Peoples R China

[41] Peking Univ, Peking Univ Int Canc Inst, Hlth Sci Ctr, Beijing 100101, Peoples R China

[42] Sichuan Univ, West China Univ Hosp 2, Key Lab Birth Defects & Related Dis Women & Child, State Key Lab Biotherapy, Chengdu 610041, Peoples R China

[43] Tongji Univ, Inst Regenerat Med, Shanghai Key Lab Signaling & Dis Res,Sch Life Sci, Frontier Sci Ctr Stem Cell Res,Shanghai East Hosp, Shanghai 200092, Peoples R China

[44] Chinese Acad Med Sci & Peking Union Med Coll, Clin Res Inst, Peking Union Med Coll Hosp, State Key Lab Complex Severe & Rare Dis, Beijing 100730, Peoples R China

[45] Beijing Tsinghua Changgung Hosp, Hepatobiliary & Pancreat Ctr, Med Res Ctr, Beijing 102218, Peoples R China

[46] Sun Yat Sen Univ, Zhongshan Sch Med, Key Lab Stem Cells & Tissue Engn, Minist Educ, Guangzhou 510080, Peoples R China

[47] Sun Yat Sen Univ, Zhongshan Sch Med, Affiliated Hosp 1, Adv Med Technol Ctr, Guangzhou 510080, Peoples R China

[48] Bioland Lab Guangzhou Regenerat Med & Hlth Guangd, Guangzhou 510005, Peoples R China

[49] Sun Yat Sen Univ, Key Lab Stem Cells & Tissue Engn, Ctr Stem Cell Biol & Tissue Engn, Minist Educ, Guangzhou 510080, Peoples R China

[50] Sun Yat Sen Univ, Zhongshan Sch Med, Natl Local Joint Engn Res Ctr Stem Cells & Regene, Guangzhou 510080, Peoples R China

来源：

SCIENCE CHINA-LIFE SCIENCES | 2023年 / 66卷 / 5期

基金：

北京市自然科学基金; 中国国家自然科学基金;

关键词：

aging; senescence; biomarker; clock; AGE-RELATED-CHANGES; HEMATOPOIETIC STEM-CELLS; NF-KAPPA-B; BROWN ADIPOSE-TISSUE; MITOCHONDRIAL-DNA MUTATIONS; SMOOTH-MUSCLE-CELLS; INTIMA-MEDIA THICKNESS; ANTI-MULLERIAN HORMONE; GLYCATION END-PRODUCTS; FOLLICLE-STIMULATING-HORMONE;

D O I：

10.1007/s11427-023-2305-0

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Aging biomarkers are a combination of biological parameters to (i) assess age-related changes, (ii) track the physiological aging process, and (iii) predict the transition into a pathological status. Although a broad spectrum of aging biomarkers has been developed, their potential uses and limitations remain poorly characterized. An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research: How old are we? Why do we get old? And how can we age slower? This review aims to address this need. Here, we summarize our current knowledge of biomarkers developed for cellular, organ, and organismal levels of aging, comprising six pillars: physiological characteristics, medical imaging, histological features, cellular alterations, molecular changes, and secretory factors. To fulfill all these requisites, we propose that aging biomarkers should qualify for being specific, systemic, and clinically relevant.

引用

页码：893 / 1066

页数：174

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