Insights into bone morphogenetic proteins in cardiovascular diseases

被引：9
|
作者：
Ye, Di [1 ,2 ,3 ]
Liu, Yinghui [4 ]
Pan, Heng [1 ,2 ,3 ]
Feng, Yongqi [1 ,2 ,3 ]
Lu, Xiyi [1 ,2 ,3 ]
Gan, Liren [1 ,2 ,3 ]
Wan, Jun [1 ,2 ,3 ]
Ye, Jing [1 ,2 ,3 ]
机构：
[1] Wuhan Univ, Dept Cardiol, Renmin Hosp, Wuhan, Peoples R China
[2] Wuhan Univ, Cardiovasc Res Inst, Wuhan, Peoples R China
[3] Hubei Key Lab Cardiol, Wuhan, Peoples R China
[4] Wuhan Univ, Dept Gastroenterol, Renmin Hosp, Wuhan, Peoples R China
来源：
FRONTIERS IN PHARMACOLOGY | 2023年 / 14卷
基金：
中国国家自然科学基金;
关键词：
BMP; atherosclerosis; vascular calcification; hypertension; cardiac remodeling; diabetic cardiomyopathy; pulmonary arterial hypertension; hereditary hemorrhagic telangiectasia; SMOOTH-MUSCLE-CELLS; GROWTH-FACTOR-BETA; PULMONARY ARTERIAL-HYPERTENSION; HUMAN ATHEROSCLEROTIC LESIONS; DIFFERENTIATION FACTOR 11; TGF-BETA; VASCULAR CALCIFICATION; OSTEOGENIC DIFFERENTIATION; WNT/BETA-CATENIN; II RECEPTOR;
D O I：
10.3389/fphar.2023.1125642
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Bone morphogenetic proteins (BMPs) are secretory proteins belonging to the transforming growth factor-beta (TGF-beta) superfamily. These proteins play important roles in embryogenesis, bone morphogenesis, blood vessel remodeling and the development of various organs. In recent years, as research has progressed, BMPs have been found to be closely related to cardiovascular diseases, especially atherosclerosis, vascular calcification, cardiac remodeling, pulmonary arterial hypertension (PAH) and hereditary hemorrhagic telangiectasia (HHT). In this review, we summarized the potential roles and related mechanisms of the BMP family in the cardiovascular system and focused on atherosclerosis and PAH.
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页数：17
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