Synthesis of Indolizines via Tf2O-Mediated Cascade Reaction of Pyridyl-enaminones with Thiophenols/Thioalcohols

被引：20

作者：

Zhang, Changyuan ^{[1
]}

Wang, Wei ^{[1
]}

Zhu, Xuncheng ^{[1
]}

Chen, Lulu ^{[1
]}

Luo, Hejiang ^{[2
]}

Guo, Mengping ^{[1
]}

Liu, Dan ^{[1
]}

Liu, Fan ^{[1
]}

Zhang, Huisheng ^{[1
]}

Li, Qi ^{[1
]}

Lin, Jianping ^{[1
]}

机构：

[1] Yichun Univ, Key Lab Jiangxi Univ Appl Chem & Chem Biol, Coll Chem & Bioengn, Yichun 336000, Peoples R China

[2] Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650500, Peoples R China

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 07期

关键词：

TRIFLIC ANHYDRIDE; ELECTROPHILIC ACTIVATION; AMIDES; TRANSFORMATIONS; TRIFLUOROMETHYLATION; DERIVATIVES; CYCLIZATION; ANNULATION; SECONDARY; KETONES;

D O I：

10.1021/acs.orglett.3c00177

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A cost-effective, highly regioselective and metal-free version for the synthesis of indolizine derivatives by means of Tf2O-mediated cascade reaction of pyridyl-enaminones and thiophenols/thioalcohols under mild reaction conditions has been reported. Diverse electron-rich indolizine derivatives could be obtained in up to 94% yield via the selective 1,4-addition of vinyl iminium triflate tandem cyclization/aromatization, which allowed the simultaneous construction of C-N and C-S/and one example of C-Se bonds.

引用

页码：1192 / 1197

页数：6

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