Construction of Vinyl-Substituted N-Heterocycles via Rh(III)- Catalyzed C-H Functionalization/Annulation of Pyrazolidinones

被引：11
作者：
Zhang, Shurui [1 ,2 ]
Hu, Shulei [3 ,4 ]
Wang, Kean [5 ]
Yang, Zhao [3 ]
Liu, Hong [2 ,3 ,4 ,5 ]
Wang, Jiang [1 ,4 ]
机构：
[1] Lingang Lab, Shanghai 200031, Peoples R China
[2] ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China
[3] China Pharmaceut Univ, 639 Longmian Ave, Nanjing 211198, Peoples R China
[4] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China
[5] Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2023年 / 365卷 / 02期
基金：
中国国家自然科学基金;
关键词：
annulation reactions; C-H activation; pyrazolidinone; Rh(III)-catalyzed; DIRECTING-GROUP; CYCLOADDITIONS; CINNOLINES; ALKYNES; ARENES;
D O I：
10.1002/adsc.202201065
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The transition-metal-catalyzed C-H activation and annulation reactions of pyrazolidinones with 4-vinyl-1,3-dioxolan-2-one or vinylene carbonate are described herein. This protocol provided two types of pyrazolo[1,2-a]cinnolines as essential assets for the development of bioactive compounds, and the synthetic practicality was performed and explained with 44 examples. The possible mechanism of these two reactions is proposed based on preliminary studies and previous reports, and no oxidant was added to both reactions.
引用
收藏
页码：238 / 243
页数：6
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