Numerical modelling of magnetic nanoparticle behavior in an alternating magnetic field based on multiphysics coupling

被引:2
作者
Ashofteh, A. [1 ,2 ,3 ]
Marques, R. [1 ]
Callejas, A. [3 ,4 ]
Munoz, R. [5 ]
Melchor, J. [1 ,2 ,3 ]
机构
[1] Univ Granada, Dept Stat & Operat Res, Granada, Spain
[2] Univ Granada, MNat Sci Unit Excellence, Granada, Spain
[3] Inst Invest Biosanitaria, Ibs GRANADA, Granada, Spain
[4] Univ Granada, Dept Struct Mech, Granada, Spain
[5] Univ Granada, Dept Civil Engn, Granada, Spain
关键词
Magnetic nanoparticle hyperthermia; alternating magnetic field; drug delivery; multiphysics; DRUG-DELIVERY; CANCER-TREATMENT; HYPERTHERMIA; DESIGN; OPTIMIZATION; LIPOSOMES;
D O I
10.1080/15376494.2022.2136805
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
In magnetic nanoparticle hyperthermia, the magnetic nanoparticles (MNPs) start oscillations when they are exposed to an alternating magnetic field, which may generate ultrasound waves. These resulting oscillations of nanoparticles can lead to the movement of drug carrier liposomes. In this study, a multiphysics coupling model of magnetic nanoparticle behavior in an alternating magnetic field was developed, implementing solid mechanics compliance parameters and piezomagnetic coupling matrices. A detailed sensitivity study was conducted to examine the effects of size and elastic modulus of MNPs, distribution and distance between two MNPs, elasticity and viscosity of the glycerol medium and mesh element sizes on the output displacement signals of MNPs. The results indicated that magnetic nanoparticles undergo some displacements when they are exposed to an alternating magnetic field. These oscillations may generate ultrasound waves, though the amount of displacement for each nanoparticle is negligibly small. It is expected that aggregated nanoparticles result in much higher oscillations.
引用
收藏
页码:1366 / 1376
页数:11
相关论文
共 45 条
  • [1] Drug delivery systems: Entering the mainstream
    Allen, TM
    Cullis, PR
    [J]. SCIENCE, 2004, 303 (5665) : 1818 - 1822
  • [2] Induced cell toxicity originates dendritic cell death following magnetic hyperthermia treatment
    Asin, L.
    Goya, G. F.
    Tres, A.
    Ibarra, M. R.
    [J]. CELL DEATH & DISEASE, 2013, 4 : e596 - e596
  • [3] Controlled Cell Death by Magnetic Hyperthermia: Effects of Exposure Time, Field Amplitude, and Nanoparticle Concentration
    Asin, L.
    Ibarra, M. R.
    Tres, A.
    Goya, G. F.
    [J]. PHARMACEUTICAL RESEARCH, 2012, 29 (05) : 1319 - 1327
  • [4] Transient solution to the bioheat equation and optimization for magnetic fluid hyperthermia treatment
    Bagaria, HG
    Johnson, DT
    [J]. INTERNATIONAL JOURNAL OF HYPERTHERMIA, 2005, 21 (01) : 57 - 75
  • [5] Numerical FEM Models for the Planning of Magnetic Induction Hyperthermia Treatments With Nanoparticles
    Candeo, A.
    Dughiero, F.
    [J]. IEEE TRANSACTIONS ON MAGNETICS, 2009, 45 (03) : 1658 - 1661
  • [6] Ultrasound generation and high-frequency motion of magnetic nanoparticles in an alternating magnetic field: Toward intracellular ultrasound therapy?
    Carrey, J.
    Connord, V.
    Respaud, M.
    [J]. APPLIED PHYSICS LETTERS, 2013, 102 (23)
  • [7] Pro-apoptotic liposomes-nanobubble conjugate synergistic with paclitaxel: a platform for ultrasound responsive image-guided drug delivery
    Chandan, Rajeet
    Banerjee, Rinti
    [J]. SCIENTIFIC REPORTS, 2018, 8
  • [8] Chikazumi S., 1997, Physics of Ferromagnetism
  • [9] Review of ultrasound mediated drug delivery for cancer treatment: updates from pre-clinical studies
    Couture, Olivier
    Foley, Jessica
    Kassell, Neal F.
    Larrat, Benoit
    Aubry, Jean-Francois
    [J]. TRANSLATIONAL CANCER RESEARCH, 2014, 3 (05) : 494 - 511
  • [10] EGFR-Targeted Magnetic Nanoparticle Heaters Kill Cancer Cells without a Perceptible Temperature Rise
    Creixell, Mar
    Bohorquez, Ana C.
    Torres-Lugo, Madeline
    Rinaldi, Carlos
    [J]. ACS NANO, 2011, 5 (09) : 7124 - 7129