O-GlcNAcylation at the center of antitumor immunity

被引：5

作者：

Heieis, Graham A. ^{[1
]}

Everts, Bart ^{[1
]}

机构：

[1] Leiden Univ Med Ctr, Dept Parasitol, Albinusdreef 2, NL-2333 ZA Leiden, Netherlands

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2023年 / 84卷

基金：

荷兰研究理事会;

关键词：

GLCNAC TRANSFERASE; GLUCOSE-METABOLISM; PROMOTE; STAT3; OGT; MICROENVIRONMENT; PHOSPHORYLATION; TRANSCRIPTION; EXPRESSION; DRIVES;

D O I：

10.1016/j.copbio.2023.103009

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The post-translational modification known as O-GlcNAcylation is a highly dysregulated process in tumors, and a key contributor to malignant transformation. In contrast, after three decades since its discovery, very little has been revealed about this process in the immune system. With the prospect of targeting O-GlcNAcylation as tumor therapy, greater understanding of how it regulates immune responses in the context of the tumor microenvironment will be needed. Here, we discuss recent discoveries from which a picture is emerging that O-GlcNAcylation, in either tumors or in immune cells, could negatively impact overall antitumor immune responses. We propose that interference with O-GlcNAcylation thus holds promise for cancer treatment from both perspectives.

引用

页数：8

共 65 条

[41] Cell-programmed nutrient partitioning in the tumour microenvironment [J].

Reinfeld, Bradley, I ;

Madden, Matthew Z. ;

Wolf, Melissa M. ;

Chytil, Anna ;

Bader, Jackie E. ;

Patterson, Andrew R. ;

Sugiura, Ayaka ;

Cohen, Allison S. ;

Ali, Ahmed ;

Do, Brian T. ;

Muir, Alexander ;

Lewis, Caroline A. ;

Hongo, Rachel A. ;

Young, Kirsten L. ;

Brown, Rachel E. ;

Todd, Vera M. ;

Huffstater, Tessa ;

Abraham, Abin ;

O'Neil, Richard T. ;

Wilson, Matthew H. ;

Xin, Fuxue ;

Tantawy, M. Noor ;

Merryman, W. David ;

Johnson, Rachelle W. ;

Williams, Christopher S. ;

Mason, Emily F. ;

Mason, Frank M. ;

Beckermann, Katherine E. ;

Vander Heiden, Matthew G. ;

Manning, H. Charles ;

Rathmell, Jeffrey C. ;

Rathmell, W. Kimryn .

NATURE, 2021, 593 (7858) :282-+

[42] Decoding endoplasmic reticulum stress signals in cancer cells and antitumor immunity [J].

Salvagno, Camilla ;

Mandula, Jessica K. ;

Rodriguez, Paulo C. ;

Cubillos-Ruiz, Juan R. .

TRENDS IN CANCER, 2022, 8 (11) :930-943

[43] Efficacy of PD-1 Blockade Is Potentiated by Metformin-Induced Reduction of Tumor Hypoxia [J].

Scharping, Nicole E. ;

Menk, Ashley V. ;

Whetstone, Ryan D. ;

Zeng, Xue ;

Delgoffe, Greg M. .

CANCER IMMUNOLOGY RESEARCH, 2017, 5 (01) :9-16

[44] Targeting tumor-intrinsic hexosamine biosynthesis sensitizes pancreatic cancer to anti-PD1 therapy [J].

Sharma, Nikita S. ;

Gupta, Vineet K. ;

Garrido, Vanessa T. ;

Hadad, Roey ;

Durden, Brittany C. ;

Kesh, Kousik ;

Giri, Bhuwan ;

Ferrantella, Anthony ;

Dudeja, Vikas ;

Saluja, Ashok ;

Banerjee, Sulagna .

JOURNAL OF CLINICAL INVESTIGATION, 2020, 130 (01) :451-465

[45] Increased glucose metabolism in TAMs fuels O-GlcNAcylation of lysosomal Cathepsin B to promote cancer metastasis and chemoresistance [J].

Shi, Qingzhu ;

Shen, Qicong ;

Liu, Yanfang ;

Shi, Yang ;

Huang, Wenwen ;

Wang, Xi ;

Li, Zhiqing ;

Chai, Yangyang ;

Wang, Hao ;

Hu, Xiangjia ;

Li, Nan ;

Zhang, Qian ;

Cao, Xuetao .

CANCER CELL, 2022, 40 (10) :1207-+

[46] Nutrient sensor O-GlcNAc transferase controls cancer lipid metabolism via SREBP-1 regulation [J].

Sodi, V. L. ;

Bacigalupa, Z. A. ;

Ferrer, C. M. ;

Lee, J. V. ;

Gocal, W. A. ;

Mukhopadhyay, D. ;

Wellen, K. E. ;

Ivan, M. ;

Reginato, M. J. .

ONCOGENE, 2018, 37 (07) :924-934

[47] STAT3 regulates CD8+ T cell differentiation and functions in cancer and acute infection [J].

Sun, Qinli ;

Zhao, Xiaohong ;

Li, Ruifeng ;

Liu, Dingfeng ;

Pan, Birui ;

Xie, Bowen ;

Chi, Xinxin ;

Cai, Dongli ;

Wei, Peng ;

Xu, Wei ;

Wei, Kun ;

Zhao, Zixuan ;

Fu, Yujie ;

Ni, Ling ;

Dong, Chen .

JOURNAL OF EXPERIMENTAL MEDICINE, 2023, 220 (04)

[48] Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy [J].

Swamy, Mahima ;

Pathak, Shalini ;

Grzes, Katarzyna M. ;

Damerow, Sebastian ;

Sinclair, Linda V. ;

van Aalten, Daan M. F. ;

Cantrell, Doreen A. .

NATURE IMMUNOLOGY, 2016, 17 (06) :712-+

[49] REGULATION AND METABOLIC FUNCTIONS OF mTORC1 AND mTORC2 [J].

Szwed, Angelia ;

Kim, Eugene ;

Jacinto, Estela .

PHYSIOLOGICAL REVIEWS, 2021, 101 (03) :1371-1426

[50] Analyzing cell-type-specific dynamics of metabolism in kidney repair [J].

Wang, Gangqi ;

Heijs, Bram ;

Kostidis, Sarantos ;

Mahfouz, Ahmed ;

Rietjens, Rosalie G. J. ;

Bijkerk, Roel ;

Koudijs, Angela ;

van der Pluijm, Lois A. K. ;

van den Berg, Cathelijne W. ;

Dumas, Sebastien J. ;

Carmeliet, Peter ;

Giera, Martin ;

van den Berg, Bernard M. ;

Rabelink, Ton J. .

NATURE METABOLISM, 2022, 4 (09) :1109-+

← 1 2 3 4 5 6 7 →