Synthesis of 3-hydroxy-1H-pyrroles and pyridazines with a sterically hindered phenol moiety

被引：0
|
作者：
Ilkov, K. V. [1 ]
Gladkikh, A. A. [1 ]
Koshelev, V. N. [1 ]
机构：
[1] Natl Univ Oil & Gas Gubkin Univ, 65 Leninsky prosp, Moscow 119991, Russia
来源：
RUSSIAN CHEMICAL BULLETIN | 2023年 / 72卷 / 09期
关键词：
2,6-di-tert-butylphenol; arylglyoxals; 3-hydroxypyrroles; pyrimido[4,5-c]-pyridazines; 3 COMPONENT SYNTHESIS; ONE-POT; PYRROLE;
D O I：
10.1007/s11172-023-4006-8
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Novel pyrroles and pyridazines were obtained by the reaction of (4-hydroxy-3,5-di-tert-butylphenyl)glyoxal with 1,3-diketones and ammonium acetate or hydrazine hydrate. The study of antioxidant activity of the synthesized compounds using ABTS and PFRAP tests showed that 7-thoxo-7,8-dihydropyrimido[4,5-c]pyridazin-5(6H)-one has the highest activity.
引用
收藏
页码：2119 / 2124
页数：6
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