Human papillomavirus vaccine impact on invasive cervical cancer in Japan: Preliminary results from cancer statistics and the MINT study

被引：2

作者：

Onuki, Mamiko ^{[1
]}

Takahashi, Fumiaki ^{[2
]}

Iwata, Takashi ^{[3
]}

Nakazawa, Hiroshi ^{[4
]}

Yahata, Hideaki ^{[5
]}

Kanao, Hiroyuki ^{[6
]}

Horie, Koji ^{[7
]}

Konnai, Katsuyuki ^{[8
]}

Nio, Ai ^{[9
]}

Takehara, Kazuhiro ^{[10
]}

Kamiura, Shoji ^{[11
]}

Tsuda, Naotake ^{[12
]}

Takei, Yuji ^{[13
]}

Shigeta, Shogo ^{[14
]}

Matsumura, Noriomi ^{[15
]}

Yoshida, Hiroyuki ^{[16
]}

Motohara, Takeshi ^{[17
]}

Yamazaki, Hiroyuki ^{[18
,19
]}

Nakamura, Keiichiro ^{[20
]}

Hamanishi, Junzo ^{[21
]}

Tasaka, Nobutaka ^{[22
]}

Ishikawa, Mitsuya ^{[23
]}

Hirashima, Yasuyuki ^{[24
]}

Kudaka, Wataru ^{[25
]}

Mori-Uchino, Mayuyo ^{[26
]}

Kukimoto, Iwao ^{[27
]}

Fujii, Takuma ^{[28
]}

Watanabe, Yoh ^{[29
]}

Noda, Kiichiro ^{[30
]}

Yoshikawa, Hiroyuki ^{[22
]}

Yaegashi, Nobuo ^{[14
]}

Matsumoto, Koji ^{[1
]}

机构：

[1] Showa Univ, Dept Obstet & Gynecol, Sch Med, Tokyo, Japan

[2] Iwate Med Univ, Div Med Engn, Dept Informat Sci, Yahaba, Japan

[3] Keio Univ, Dept Obstet & Gynecol, Sch Med, Tokyo, Japan

[4] Hyogo Canc Ctr, Dept Gynecol Oncol, Akashi, Japan

[5] Kyushu Univ, Grad Sch Med Sci, Dept Obstet & Gynecol, Fukuoka, Japan

[6] Canc Inst Hosp, Dept Gynecol, Tokyo, Japan

[7] Saitama Canc Ctr, Dept Gynecol, Saitama, Japan

[8] Kanagawa Canc Ctr, Dept Gynecol, Yokohama, Kanagawa, Japan

[9] Natl Hosp Org Kyushu Canc Ctr, Gynecol Serv, Fukuoka, Japan

[10] Natl Hosp Org Shikoku Canc Ctr, Dept Gynecol Oncol, Matsuyama, Japan

[11] Osaka Int Canc Inst, Dept Gynecol, Osaka, Japan

[12] Kurume Univ, Dept Obstet & Gynecol, Sch Med, Kurume, Japan

[13] Jichi Med Univ, Dept Obstet & Gynecol, Shimotsuke, Tochigi, Japan

[14] Tohoku Univ, Dept Obstet & Gynecol, Grad Sch Med, Sendai, Japan

[15] Kindai Univ, Dept Obstet & Gynecol, Fac Med, Osaka, Japan

[16] Saitama Med Univ, Dept Gynecol Oncol, Int Med Ctr, Saitama, Japan

[17] Kumamoto Univ, Dept Obstet & Gynecol, Fac Life Sci, Kumamoto, Japan

[18] Hokkaido Univ, Dept Obstet & Gynecol, Grad Sch Med, Sapporo, Japan

[19] Hokkaido Univ, Fac Med, Sapporo, Japan

[20] Okayama Univ, Dept Obstet & Gynecol, Grad Sch Med Dent & Pharmaceut Sci, Okayama, Japan

[21] Kyoto Univ, Dept Gynecol & Obstet, Grad Sch Med, Kyoto, Japan

[22] Univ Tsukuba, Dept Obstet & Gynecol, Fac Med, Tsukuba, Japan

[23] Natl Canc Ctr, Dept Gynecol, Tokyo, Japan

[24] Shizuoka Canc Ctr Hosp, Div Gynecol, Shizuoka, Japan

[25] Univ Ryukyus, Grad Sch Med, Dept Obstet & Gynecol, Okinawa, Japan

[26] Univ Tokyo, Grad Sch Med, Dept Obstet & Gynecol, Tokyo, Japan

[27] Natl Inst Infect Dis, Pathogen Genom Ctr, Tokyo, Japan

[28] Fujita Hlth Univ, Sch Med, Dept Gynecol, Toyoake, Aichi, Japan

[29] Tohoku Med & Pharmaceut Univ, Div Obstet & Gynecol, Grad Sch Med, Sendai, Japan

[30] Kindai Univ, Osaka, Japan

来源：

CANCER SCIENCE | 2023年 / 114卷 / 11期

关键词：

cancer registry; cervical cancer; human papillomavirus; incidence; vaccination;

D O I：

10.1111/cas.15943

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The first prophylactic vaccine against human papillomavirus (HPV) 16 and HPV18 was licensed in Japan in 2009. HPV vaccine effectiveness against high-grade cervical lesions has been demonstrated among young Japanese women, but evidence of its effects on invasive cervical cancer (ICC) is lacking. Using data from two different cancer registries, we compared recent trends of new ICC cases by age group using Poisson regression analysis. We also analyzed time trends in HPV16/18 prevalence among 1414 Japanese women aged <40 years newly diagnosed with ICC in the past decade. Based on the population-based cancer registry, the incidence of ICC among young women aged 20-29 years showed a significant decline from 3.6 to 2.8 per 100 000 women-years during 2016-2019, but no similar decline was observed for older age groups (p < 0.01). Similarly, using data from the gynecological cancer registry of the Japan Society of Obstetrics and Gynecology, the annual number of ICCs among women aged 20-29 years also decreased from 256 cases to 135 cases during 2011-2020 (p < 0.0001). Furthermore, a declining trend in HPV16/18 prevalence in ICC was observed only among women aged 20-29 years during 2017-2022 (90.5%-64.7%, p = 0.05; Cochran-Armitage trend test). This is the first report to suggest population-level effects of HPV vaccination on ICC in Japan. Although the declining trend in HPV16/18 prevalence among young women with ICC supports a causal linkage between vaccination and results from cancer registries, further studies are warranted to confirm that our findings are attributable to vaccination.

引用

页码：4426 / 4432

页数：7

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