Association between sick sinus syndrome and atrial fibrillation: A systematic review and meta-analysis

被引：7

作者：

Liu, Ying ^{[1
]}

Zheng, Yi ^{[1
]}

Tse, Gary ^{[1
,2
,3
,4
]}

Bazoukis, George ^{[5
,6
]}

Letsas, Konstantinos ^{[7
]}

Goudis, Christos ^{[8
]}

Korantzopoulos, Panagiotis ^{[9
]}

Li, Guangping ^{[1
]}

Liu, Tong ^{[1
]}

机构：

[1] Tianjin Med Univ, Tianjin Inst Cardiol, Tianjin Key Lab Ion Mol Funct Cardiovasc Dis, Dept Cardiol,Hosp 2, Tianjin 300211, Peoples R China

[2] Univ Kent, Kent & Medway Med Sch, Canterbury, England

[3] Canterbury Christ Church Univ, Canterbury, England

[4] Hong Kong Metropolitan Univ, Sch Nursing & Hlth Studies, Hong Kong, Peoples R China

[5] Larnaca Gen Hosp, Dept Cardiol, Inomenon Polit Amerikis, Larnax, Cyprus

[6] Univ Nicosia, Dept Basic & Clin Sci, Med Sch, CY-2414 Nicosia, Cyprus

[7] Onassis Cardiac Surg Ctr, Lab Cardiac Electrophysiol, Athens, Greece

[8] Serres Gen Hosp, Dept Cardiol, Serres 45110, Greece

[9] Univ Ioannina, Dept Cardiol 1, Med Sch, Ioannina, Greece

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2023年 / 381卷

基金：

中国国家自然科学基金;

关键词：

Sick sinus syndrome; Atrial fibrillation; Pacemaker; Catheter ablation; TACHYCARDIA-BRADYCARDIA SYNDROME; NODE DYSFUNCTION; CATHETER ABLATION; INTERATRIAL SEPTUM; ELECTIVE REPLACEMENT; PERMANENT PACEMAKER; CLINICAL-OUTCOMES; PREVENTION; EFFICACY; PATHOPHYSIOLOGY;

D O I：

10.1016/j.ijcard.2023.03.066

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims: Sick sinus syndrome (SSS) and atrial fibrillation (AF) frequently coexist and show a bidirectional relationship. This systematic review and meta-analysis aimed to decipher the precise relationship between SSS and AF, further exploring and comparing different therapy strategies on the occurrence or progression of AF in patients with SSS. Methods and results: A systematic literature search was conducted until November 2022. A total of 35 articles with 37,550 patients were included. Patients with SSS were associated with new-onset AF compared to those without SSS. Catheter ablation was associated with a lower risk of AF recurrence, AF progression, all-cause mortality, stroke and hospitalization of heart failure compared to pacemaker therapy. Regarding the different pacing strategies for SSS, VVI/VVIR has higher risk of new-onset AF than DDD/DDDR. No significant difference was found between AAI/AAIR and DDD/DDDR, as well as between DDD/DDDR and minimal ventricular pacing (MVP) for AF recurrence. AAI/AAIR was associated with higher risk of all-cause mortality when compared to DDD/DDDR, but lower risk of cardiac death when compared to DDD/DDDR. Right atrial septum pacing was associated with a similar risk of new-onset AF or AF recurrence compared to right atrial appendage pacing. Conclusion: SSS is associated with a higher risk of AF. For patients with both SSS and AF, catheter ablation should be considered. This meta-analysis re-emphasizes that high percentage of ventricular pacing should be avoided in patients with SSS in order to decrease AF burden and mortality.

引用

页码：20 / 36

页数：17