From mitochondria to sarcopenia: role of 17β-estradiol and testosterone

被引:18
作者
Tian, Xu [1 ]
Lou, Shujie [1 ]
Shi, Rengfei [1 ]
机构
[1] Shanghai Univ Sport, Sch Kinesiol, Shanghai, Peoples R China
来源
FRONTIERS IN ENDOCRINOLOGY | 2023年 / 14卷
基金
上海市自然科学基金;
关键词
skeletal muscle; mitochondria; sarcopenia; 17; beta-estradiol; testosterone; aging; SKELETAL-MUSCLE MITOCHONDRIAL; GENE-EXPRESSION; OXIDATIVE CAPACITY; SEX-DIFFERENCES; ESTROGEN; BIOGENESIS; MITOPHAGY; CALCIUM; AGE; PGC-1-ALPHA;
D O I
10.3389/fendo.2023.1156583
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Sarcopenia, characterized by a loss of muscle mass and strength with aging, is prevalent in older adults. Although the exact mechanisms underlying sarcopenia are not fully understood, evidence suggests that the loss of mitochondrial integrity in skeletal myocytes has emerged as a pivotal contributor to the complex etiology of sarcopenia. Mitochondria are the primary source of ATP production and are also involved in generating reactive oxygen species (ROS), regulating ion signals, and initiating apoptosis signals in muscle cells. The accumulation of damaged mitochondria due to age-related impairments in any of the mitochondrial quality control ( MQC) processes, such as proteostasis, biogenesis, dynamics, and mitophagy, can contribute to the decline in muscle mass and strength associated with aging. Interestingly, a decrease in sex hormones (e.g., 17 beta-estradiol and testosterone), which occurs with aging, has also been linked to sarcopenia. Indeed, 17 beta-estradiol and testosterone targeted mitochondria and exhibited activities in regulating mitochondrial functions. Here, we overview the current literature on the key mechanisms by which mitochondrial dysfunction contribute to the development and progression of sarcopenia and the potential modulatory effects of the development of potential therapeutic agents to mitigate and manage sarcopenia.
引用
收藏
页数:12
相关论文
共 159 条
  • [81] Sarcopenia and cachexia in chronic diseases: from mechanisms to treatment
    Lena, Alessia
    Hadzibegovic, Sara
    von Haehling, Stephan
    Springer, Jochen
    Coats, Andrew J. Stewart
    Anker, Markus S.
    [J]. POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ, 2021, 131 (12):
  • [82] Mitochondria-Associated Degradation Pathway (MAD) Function beyond the Outer Membrane
    Liao, Pin-Chao
    Wolken, Dana M. Alessi
    Serrano, Edith
    Srivastava, Pallavi
    Pon, Liza A.
    [J]. CELL REPORTS, 2020, 32 (02):
  • [83] Mitochondrial translocation of estrogen receptor β affords resistance to oxidative insult-induced apoptosis and contributes to the pathogenesis of endometriosis
    Liao, Tien-Ling
    Lee, Yu-Ching
    Tzeng, Chii-Ruey
    Wang, Yi-Pei
    Chang, Heng-Yu
    Lin, Yung-Feng
    Kao, Shu-Huei
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2019, 134 : 359 - 373
  • [84] Multiple environmental and genetic factors influence skeletal muscle PGC-1α and PGC-1β gene expression in twins
    Ling, C
    Poulsen, P
    Carlsson, E
    Ridderstråle, M
    Almgren, P
    Wojtaszewski, J
    Beck-Nielsen, H
    Groop, L
    Vaag, A
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (10) : 1518 - 1526
  • [85] Testosterone Deficiency Caused by Castration Modulates Mitochondria Biogenesis Through the AR/PGC1α/TFAM Pathway
    Liu, Can
    Ma, Jideng
    Zhang, Jinwei
    Zhao, Han
    Zhu, Yan
    Qi, Jing
    Liu, Lingyan
    Zhu, Li
    Jiang, Yanzhi
    Tang, Guoqing
    Li, Xuewei
    Li, Mingzhou
    [J]. FRONTIERS IN GENETICS, 2019, 10
  • [86] Dysregulations of mitochondrial quality control and autophagic flux at an early age lead to progression of sarcopenia in SAMP8 mice
    Liu, Hung-Wen
    Chang, Yun-Ching
    Chan, Yin-Ching
    Hu, Shu-Hui
    Liu, Ming-Yi
    Chang, Sue-Joan
    [J]. BIOGERONTOLOGY, 2020, 21 (03) : 367 - 380
  • [87] Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission
    Loson, Oliver C.
    Song, Zhiyin
    Chen, Hsiuchen
    Chan, David C.
    [J]. MOLECULAR BIOLOGY OF THE CELL, 2013, 24 (05) : 659 - 667
  • [88] Circulating Mitochondrial-Derived Vesicles, Inflammatory Biomarkers and Amino Acids in Older Adults With Physical Frailty and Sarcopenia: A Preliminary BIOSPHERE Multi-Marker Study Using Sequential and Orthogonalized Covariance Selection - Linear Discriminant Analysis
    Marzetti, Emanuele
    Guerra, Flora
    Calvani, Riccardo
    Marini, Federico
    Biancolillo, Alessandra
    Gervasoni, Jacopo
    Primiano, Aniello
    Coelho-Junior, Helio Jose
    Landi, Francesco
    Bernabei, Roberto
    Bucci, Cecilia
    Picca, Anna
    [J]. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2020, 8
  • [89] Association between myocyte quality control signaling and sarcopenia in old hip-fractured patients: Results from the Sarcopenia in HIp FracTure (SHIFT) exploratory study
    Marzetti, Emanuele
    Calvani, Riccardo
    Lorenzi, Maria
    Tanganelli, Fabiana
    Picca, Anna
    Bossola, Maurizio
    Menghi, Amerigo
    Bernabei, Roberto
    Landi, Francesco
    [J]. EXPERIMENTAL GERONTOLOGY, 2016, 80 : 1 - 5
  • [90] X-chromosome-linked miR548am-5p is a key regulator of sex disparity in the susceptibility to mitochondria-mediated apoptosis
    Matarrese, Paola
    Tieri, Paolo
    Anticoli, Simona
    Ascione, Barbara
    Conte, Maria
    Franceschi, Claudio
    Malorni, Walter
    Salvioli, Stefano
    Ruggieri, Anna
    [J]. CELL DEATH & DISEASE, 2019, 10 (9)