Neurovascular coupling (NVC) modulates cerebral blood flow to match increased metabolic demand during neuronal excitation. Activation of inhibitory interneurons also increase blood flow, but the basis for NVC caused by interneurons is unclear. While astrocyte Ca2+ levels rise with excitatory neural transmission, much less is known with regards to astrocytic sensitivity to inhibitory neurotransmission. We performed two-photon microscopy in awake mice to examine the correlation between astrocytic Ca2+ and NVC, evoked by activation of either all (VGAT(IN)) or only parvalbumin-positive GABAergic interneurons (PVIN). Optogenetic stimulation of VGAT(IN) and PVIN in the somatosensory cortex triggered astrocytic Ca2+ increases that were abolished by anesthesia. In awake mice, PVIN evoked astrocytic Ca2+ responses with a short latency that preceded NVC, whereas VGAT(IN) evoked Ca2+ increases that were delayed relative to the NVC response. The early onset of PVIN evoked astrocytic Ca2+ increases depended on noradrenaline release from locus coeruleus as did the subsequent NVC response. Though the relationship between interneuron activity and astrocytic Ca2+ responses is complex, we suggest that the rapid astrocyte Ca2+ responses to increased PVIN activity shaped the NVC. Our results underline that interneuron and astrocyte-dependent mechanisms should be studied in awake mice.
机构:
Univ British Columbia, Dept Psychiat, Brain Res Inst, Vancouver, BC V6T 2B5, CanadaUniv British Columbia, Dept Psychiat, Brain Res Inst, Vancouver, BC V6T 2B5, Canada
Mulligan, SJ
MacVicar, BA
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Univ British Columbia, Dept Psychiat, Brain Res Inst, Vancouver, BC V6T 2B5, CanadaUniv British Columbia, Dept Psychiat, Brain Res Inst, Vancouver, BC V6T 2B5, Canada
机构:
Univ Calif Los Angeles, Dept Physiol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Physiol, Los Angeles, CA 90095 USA
Nagai, Jun
Rajbhandari, Abha K.
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Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Physiol, Los Angeles, CA 90095 USA
Rajbhandari, Abha K.
Gangwani, Mohitkumar R.
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Univ Calif Los Angeles, Dept Physiol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Physiol, Los Angeles, CA 90095 USA
Gangwani, Mohitkumar R.
Hachisuka, Ayaka
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Univ Calif Los Angeles, Dept Neurobiol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Physiol, Los Angeles, CA 90095 USA
Hachisuka, Ayaka
Coppola, Giovanni
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Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Ctr Neurobehav Genet, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Physiol, Los Angeles, CA 90095 USA
Coppola, Giovanni
Masmanidis, Sotiris C.
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Univ Calif Los Angeles, Dept Neurobiol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Physiol, Los Angeles, CA 90095 USA
Masmanidis, Sotiris C.
Fanselow, Michael S.
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Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Physiol, Los Angeles, CA 90095 USA
Fanselow, Michael S.
Khakh, Baljit S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Dept Physiol, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Dept Neurobiol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Physiol, Los Angeles, CA 90095 USA
机构:
Univ British Columbia, Dept Psychiat, Brain Res Inst, Vancouver, BC V6T 2B5, CanadaUniv British Columbia, Dept Psychiat, Brain Res Inst, Vancouver, BC V6T 2B5, Canada
Mulligan, SJ
MacVicar, BA
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h-index: 0
机构:
Univ British Columbia, Dept Psychiat, Brain Res Inst, Vancouver, BC V6T 2B5, CanadaUniv British Columbia, Dept Psychiat, Brain Res Inst, Vancouver, BC V6T 2B5, Canada
机构:
Univ Calif Los Angeles, Dept Physiol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Physiol, Los Angeles, CA 90095 USA
Nagai, Jun
Rajbhandari, Abha K.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Physiol, Los Angeles, CA 90095 USA
Rajbhandari, Abha K.
Gangwani, Mohitkumar R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Dept Physiol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Physiol, Los Angeles, CA 90095 USA
Gangwani, Mohitkumar R.
Hachisuka, Ayaka
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Dept Neurobiol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Physiol, Los Angeles, CA 90095 USA
Hachisuka, Ayaka
Coppola, Giovanni
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Ctr Neurobehav Genet, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Physiol, Los Angeles, CA 90095 USA
Coppola, Giovanni
Masmanidis, Sotiris C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Dept Neurobiol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Physiol, Los Angeles, CA 90095 USA
Masmanidis, Sotiris C.
Fanselow, Michael S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Physiol, Los Angeles, CA 90095 USA
Fanselow, Michael S.
Khakh, Baljit S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Dept Physiol, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Dept Neurobiol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Physiol, Los Angeles, CA 90095 USA