Tumor Microenvironment Regulation and Cancer Targeting Therapy Based on Nanoparticles

被引:8
|
作者
Han, Shulan [1 ]
Chi, Yongjie [2 ,3 ]
Yang, Zhu [2 ,3 ]
Ma, Juan [4 ]
Wang, Lianyan [2 ,3 ]
机构
[1] Jilin Univ, Sch Pharmaceut Sci, Changchun 130021, Peoples R China
[2] Chinese Acad Sci, Inst Proc Engn, Key Lab Green Proc & Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[4] Capital Med Univ, Beijing Shijitan Hosp, Dept Clin Lab Med, Beijing 100038, Peoples R China
基金
北京市自然科学基金; 中国国家自然科学基金;
关键词
antitumor therapy; tumor; microenvironment regulation; nanoparticles; MESOPOROUS SILICA NANOPARTICLES; POLYMER HYBRID NANOPARTICLES; ENHANCES VACCINE THERAPY; DRUG-DELIVERY; BREAST-CANCER; GOLD NANOPARTICLES; PHOTODYNAMIC THERAPY; PHASE-I; MESSENGER-RNA; MULTIFUNCTIONAL NANOPARTICLES;
D O I
10.3390/jfb14030136
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Although we have made remarkable achievements in cancer awareness and medical technology, there are still tremendous increases in cancer incidence and mortality. However, most anti-tumor strategies, including immunotherapy, show low efficiency in clinical application. More and more evidence suggest that this low efficacy may be closely related to the immunosuppression of the tumor microenvironment (TME). The TME plays a significant role in tumorigenesis, development, and metastasis. Therefore, it is necessary to regulate the TME during antitumor therapy. Several strategies are developing to regulate the TME as inhibiting tumor angiogenesis, reversing tumor associated macrophage (TAM) phenotype, removing T cell immunosuppression, and so on. Among them, nanotechnology shows great potential for delivering regulators into TME, which further enhance the antitumor therapy efficacy. Properly designed nanomaterials can carry regulators and/or therapeutic agents to eligible locations or cells to trigger specific immune response and further kill tumor cells. Specifically, the designed nanoparticles could not only directly reverse the primary TME immunosuppression, but also induce effective systemic immune response, which would prevent niche formation before metastasis and inhibit tumor recurrence. In this review, we summarized the development of nanoparticles (NPs) for anti-cancer therapy, TME regulation, and tumor metastasis inhibition. We also discussed the prospect and potential of nanocarriers for cancer therapy.
引用
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页数:26
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