New insights of DsbA-L in the pathogenesis of metabolic diseases

被引：0
|
作者：
Li, Siqi [1 ,2 ,3 ]
Wan, Jinfa [4 ]
Peng, Zhenyu [5 ,6 ]
Huang, Qiong [1 ,2 ,3 ]
He, Baimei [1 ,2 ,3 ]
机构：
[1] Cent South Univ, Xiangya Hosp, Dept Geriatr Resp & Crit Care Med, Changsha 410008, Peoples R China
[2] Cent South Univ, Xiangya Hosp, Dept Geriatr Med, Changsha 410008, Peoples R China
[3] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Peoples R China
[4] Army Med Univ, Southwest Hosp, Dept Emergency Med, Chongqing 400038, Peoples R China
[5] Cent South Univ, Xiangya Hosp 2, Dept Emergency Med, Changsha 410011, Peoples R China
[6] Cent South Univ, Emergency Med & Difficult Dis Inst, Changsha 410011, Peoples R China
来源：
MOLECULAR AND CELLULAR BIOCHEMISTRY | 2024年 / 479卷 / 12期
关键词：
DsbA-L; Metabolic diseases; Obesity; Diabetes mellitus; NAFLD; MOLECULAR-WEIGHT ADIPONECTIN; DOWN-REGULATION; L GENE; INSULIN-RESISTANCE; TRANSFERASE-KAPPA; DISULFIDE-BOND; UP-REGULATION; ER STRESS; EXPRESSION; INFLAMMATION;
D O I：
10.1007/s11010-024-04964-8
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Metabolic diseases, such as obesity, diabetes mellitus, and non-alcoholic fatty liver disease (NAFLD), are abnormal conditions that result from disturbances of metabolism. With the improvement of living conditions, the morbidity and mortality rates of metabolic diseases are steadily rising, posing a significant threat to human health worldwide. Therefore, identifying novel effective targets for metabolic diseases is crucial. Accumulating evidence has indicated that disulfide bond A oxidoreductase-like protein (DsbA-L) delays the development of metabolic diseases. However, the underlying mechanisms of DsbA-L in metabolic diseases remain unclear. In this review, we will discuss the roles of DsbA-L in the pathogenesis of metabolic diseases, including obesity, diabetes mellitus, and NAFLD, and highlight the potential mechanisms. These findings suggest that DsbA-L might provide a novel therapeutic strategy for metabolic diseases.
引用
收藏
页码：3293 / 3303
页数：11
相关论文
共 50 条
  • [1] DsbA-L: A Promising Therapeutic Target for Metabolic Diseases
    Yang, Ming
    Luo, Shilu
    Yang, Jinfei
    Chen, Wei
    He, Liyu
    Liu, Di
    Wang, Xi
    Xiao, Li
    Sun, Lin
    CURRENT MEDICINAL CHEMISTRY, 2025, 32 (05) : 982 - 991
  • [2] DsbA-L mediated renal tubulointerstitial fibrosis in UUO mice
    Li, Xiaozhou
    Pan, Jian
    Li, Huiling
    Li, Guangdi
    Liu, Xiangfeng
    Liu, Bohao
    He, Zhibiao
    Peng, Zhengyu
    Zhang, Hongliang
    Li, Yijian
    Xiang, Xudong
    Chai, Xiangping
    Yuan, Yunchang
    Zheng, Peilin
    Liu, Feng
    Zhang, Dongshan
    NATURE COMMUNICATIONS, 2020, 11 (01)
  • [3] DsbA-L Alleviates Endoplasmic Reticulum Stress-Induced Adiponectin Downregulation
    Zhou, Lijun
    Liu, Meilian
    Zhang, Jingjing
    Chen, Hongzhi
    Dong, Lily Q.
    Liu, Feng
    DIABETES, 2010, 59 (11) : 2809 - 2816
  • [4] DsbA-L ameliorates renal aging and renal fibrosis by maintaining mitochondrial homeostasis
    Yang, Ming
    Liu, Yan
    Luo, Shi-lu
    Liu, Chong-bin
    Jiang, Na
    Li, Chen-rui
    Zhao, Hao
    Han, Ya-chun
    Chen, Wei
    Li, Li
    Sun, Lin
    ACTA PHARMACOLOGICA SINICA, 2024, 45 (04) : 777 - 789
  • [5] DsbA-L ameliorates high glucose induced tubular damage through maintaining MAM integrity
    Yang, Ming
    Zhao, Li
    Gao, Peng
    Zhu, Xuejing
    Han, Yachun
    Chen, Xianghui
    Li, Li
    Xiao, Ying
    Wei, Ling
    Li, Chenrui
    Xiao, Li
    Yuan, Shuguang
    Liu, Fuyou
    Dong, Lily Q.
    Kanwar, Yashpal S.
    Sun, Lin
    EBIOMEDICINE, 2019, 43 : 607 - 619
  • [6] The DsbA-L gene is associated with respiratory function of the elderly via its adiponectin multimeric or antioxidant properties
    Oniki, Kentaro
    Nohara, Hirofumi
    Nakashima, Ryunosuke
    Obata, Yui
    Muto, Narumi
    Sakamoto, Yuki
    Ueno-Shuto, Keiko
    Imafuku, Tadashi
    Ishima, Yu
    Watanabe, Hiroshi
    Maruyama, Toru
    Otake, Koji
    Ogata, Yasuhiro
    Suico, Mary Ann
    Kai, Hirofumi
    Shuto, Tsuyoshi
    Saruwatari, Junji
    SCIENTIFIC REPORTS, 2020, 10 (01)
  • [7] DsbA-L deletion attenuates LPS-induced acute kidney injury by modulating macrophage polarization
    Cui, Pengcheng
    Chen, Chao
    Cui, Yan
    Qiu, Xia
    Yue, Kaiye
    Li, Tengfang
    Zhang, Hedong
    Yuan, Wenjia
    Xie, Yixin
    Guo, Yong
    Tang, Zhouqi
    Li, Yaguang
    Peng, Fenghua
    Jiang, Xin
    Luo, Xuewei
    Peng, Longkai
    Qi, Zhongquan
    Dai, Helong
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2023, 53 (10)
  • [8] DsbA-L interacting with catalase in peroxisome improves tubular oxidative damage in diabetic nephropathy
    Liu, Yan
    Chen, Wei
    Li, Chenrui
    Li, Li
    Yang, Ming
    Jiang, Na
    Luo, Shilu
    Xi, Yiyun
    Liu, Chongbin
    Han, Yachun
    Zhao, Hao
    Zhu, Xuejing
    Yuan, Shuguang
    Xiao, Li
    Sun, Lin
    REDOX BIOLOGY, 2023, 66
  • [9] A disulfide-bond A oxidoreductase-like protein (DsbA-L) regulates adiponectin multimerization
    Liu, Meilian
    Zhou, Lijun
    Xu, Aimin
    Lam, Karen S. L.
    Wetzel, Michael D.
    Xiang, Ruihua
    Zhang, Jingjing
    Xin, Xiaoban
    Dong, Lily Q.
    Liu, Feng
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (47) : 18302 - 18307
  • [10] Peroxisome proliferator-activated receptor γ enhances adiponectin secretion via up-regulating DsbA-L expression
    Jin, Dan
    Sun, Jun
    Huang, Jing
    Yu, Xiaoling
    Yu, An
    He, Yiduo
    Li, Qiang
    Yang, Zaiqing
    MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2015, 411 (0C) : 97 - 104
12345