Transfer RNA modifications and cellular thermotolerance

被引：11
|
作者：
Ohira, Takayuki [1 ]
Suzuki, Tsutomu [1 ]
机构：
[1] Univ Tokyo, Grad Sch Engn, Dept Chem & Biotechnol, 7-3-1 Hongo,Bunkyo Ku, Tokyo 1138656, Japan
来源：
MOLECULAR CELL | 2024年 / 84卷 / 01期
基金：
日本科学技术振兴机构;
关键词：
PHENYLALANINE TRANSFER-RNA; S RIBOSOMAL-RNA; POSTTRANSCRIPTIONAL MODIFICATIONS; N-4-ACETYLCYTIDINE FORMATION; EXTREME THERMOPHILE; MODIFIED NUCLEOSIDE; THERMAL-STABILITY; GENE-EXPRESSION; HUMAN NAT10; ACETYLTRANSFERASE;
D O I：
10.1016/j.molcel.2023.11.041
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
RNA molecules are modified post -transcriptionally to acquire their diverse functions. Transfer RNA (tRNA) has the widest variety and largest numbers of RNA modifications. tRNA modifications are pivotal for decoding the genetic code and stabilizing the tertiary structure of tRNA molecules. Alternation of tRNA modifications directly modulates the structure and function of tRNAs and regulates gene expression. Notably, thermophilic organisms exhibit characteristic tRNA modifications that are dynamically regulated in response to varying growth temperatures, thereby bolstering fitness in extreme environments. Here, we review the history and latest findings regarding the functions and biogenesis of several tRNA modifications that contribute to the cellular thermotolerance of thermophiles.
引用
收藏
页码：94 / 106
页数：13
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