The role of cancer-associated fibroblasts in bladder cancer progression

被引：6

作者：

Huang, Long ^{[1
]}

Xie, Qun ^{[1
]}

Deng, Jian ^{[1
]}

Wei, Wen-Fei ^{[2
,3
]}

机构：

[1] Jinan Univ, Zhuhai Peoples Hosp, Zhuhai Hosp, Dept Urol, Zhuhai, Guangdong, Peoples R China

[2] Jinan Univ, Zhuhai Peoples Hosp, Zhuhai Hosp, Dept Gynecol, Zhuhai, Guangdong, Peoples R China

[3] Guangzhou Med Univ, Affiliated Hosp 1, Dept Obstet & Gynaecol, Guangzhou, Guangdong, Peoples R China

来源：

HELIYON | 2023年 / 9卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Bladder cancer; Cancer-associated fibroblasts; Proliferation; Invasion and metastasis; Chemotherapy resistance; TUMOR PROGRESSION; CELLS; URINARY; CARCINOMA; PROLIFERATION; ACTIVATION; CONTRIBUTE; TENASCIN; INVASION; NICHE;

D O I：

10.1016/j.heliyon.2023.e19802

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cancer-associated fibroblasts (CAFs) are key stromal cells in the tumor microenvironment (TME) that critically contribute to cancer initiation and progression. In bladder cancer (BCa), there is emerging evidence that BCa CAFs are actively involved in cancer cell proliferation, invasion, metastasis, and chemotherapy resistance. This review outlines the present knowledge of BCa CAFs, with a particular emphasis on their origin and function in BCa progression, and provides further insights into their clinical application.

引用

页数：11

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