Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation

被引：285

作者：

Chehelgerdi, Mohammad ^{[1
,2
]}

Chehelgerdi, Matin ^{[1
,2
]}

Allela, Omer Qutaiba B. ^{[3
]}

Pecho, Renzon Daniel Cosme ^{[4
]}

Jayasankar, Narayanan ^{[5
]}

Rao, Devendra Pratap ^{[6
]}

Thamaraikani, Tamilanban ^{[5
]}

Vasanthan, Manimaran ^{[7
]}

Viktor, Patrik ^{[8
]}

Lakshmaiya, Natrayan ^{[9
]}

Saadh, Mohamed J. ^{[10
]}

Amajd, Ayesha ^{[11
,12
]}

Abo-Zaid, Mabrouk A. ^{[13
]}

Castillo-Acobo, Roxana Yolanda ^{[14
]}

Ismail, Ahmed H. ^{[13
]}

Amin, Ali H. ^{[15
]}

Akhavan-Sigari, Reza ^{[16
,17
]}

机构：

[1] Novin Genome NG Inst, Res & Dev Ctr Biotechnol, Shahrekord, Chaharmahal & B, Iran

[2] Islamic Azad Univ, Shahrekord Branch, Young Researchers & Elite Club, Shahrekord, Iran

[3] Al Noor Univ Coll, Dept Pharm, Nineveh, Iraq

[4] Univ San Ignacio Loyola USIL, Dept Biochem, Lima, Peru

[5] SRM Coll Pharm, SRM Inst Sci & Technol, Dept Pharmacol, Kattankulathur 603203, Tamil Nadu, India

[6] Dayanand Anglo Ved PG Coll, Dept Chem, Coordinat Chem Lab, Kanpur 208001, UP, India

[7] SRM Coll Pharm, SRM Inst Sci & Technol, Dept Pharmaceut, Kattankulathur 603203, Tamil Nadu, India

[8] Obuda Univ, Kelet Karoly Fac Business & Management, Tavaszmezo U 15-17, H-1084 Budapest, Hungary

[9] SIMATS, Saveetha Sch Engn, Dept Mech Engn, Chennai, Tamil Nadu, India

[10] Middle East Univ, Fac Pharm, Amman 11831, Jordan

[11] Silesian Tech Univ, Fac Org & Management, PL-44100 Gliwice, Poland

[12] Univ Coimbra, CEMMPRE, Dept Mech Engn, Polo 2, P-3030788 Coimbra, Portugal

[13] Jazan Univ, Coll Sci, Dept Biol, Jazan 82817, Saudi Arabia

[14] Univ Nacl San Agustin Arequipa, Arequipa, Peru

[15] Umm Al Qura Univ, Sci Res, Mecca 21955, Saudi Arabia

[16] Univ Med Ctr, Dept Neurosurg, Tubingen, Germany

[17] Warsaw Management Univ Warsaw, Coll Humanum, Dept Hlth Care Management & Clin Res, Warsaw, Poland

来源：

MOLECULAR CANCER | 2023年 / 22卷 / 01期

关键词：

Nanotechnology; Cancer detection; Cancer treatment; Nanoscale targeting techniques; Protein engineering; Materials science; Nanocarriers; Medicinal purposes; Human trials; SUPERPARAMAGNETIC IRON-OXIDE; DRUG-DELIVERY SYSTEM; POLYMERIC NANOPARTICLES; GOLD NANOPARTICLES; CARBON NANOTUBES; IN-VITRO; THERAPY; GENE; TUMOR; NANOCARRIERS;

D O I：

10.1186/s12943-023-01865-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The use of nanotechnology has the potential to revolutionize the detection and treatment of cancer. Developments in protein engineering and materials science have led to the emergence of new nanoscale targeting techniques, which offer renewed hope for cancer patients. While several nanocarriers for medicinal purposes have been approved for human trials, only a few have been authorized for clinical use in targeting cancer cells. In this review, we analyze some of the authorized formulations and discuss the challenges of translating findings from the lab to the clinic. This study highlights the various nanocarriers and compounds that can be used for selective tumor targeting and the inherent difficulties in cancer therapy. Nanotechnology provides a promising platform for improving cancer detection and treatment in the future, but further research is needed to overcome the current limitations in clinical translation.

引用

页数：103

共 329 条

[1] Synthesis and characterization of actively HER-2 Targeted Fe3O4@Au nanoparticles for molecular radiosensitization of breast cancer
Abdollahi, Behnaz Babaye
Ghorbani, Marjan
Hamishehkar, Hamed
Malekzadeh, Reza
Farajollahi, Ali Reza
[J]. BIOIMPACTS, 2023, 13 (01) : 17 - 29
[2] A comprehensive update of siRNA delivery design strategies for targeted and effective gene silencing in gene therapy and other applications
Abosalha, Ahmed Khaled
Ahmad, Waqar
Boyajian, Jacqueline
Islam, Paromita
Ghebretatios, Merry
Schaly, Sabrina
Thareja, Rahul
Arora, Karan
Prakash, Satya
[J]. EXPERT OPINION ON DRUG DISCOVERY, 2023, 18 (02) : 149 - 161
[3] C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector
Abudayyeh, Omar O.
Gootenberg, Jonathan S.
Konermann, Silvana
Joung, Julia
Slaymaker, Ian M.
Cox, David B. T.
Shmakov, Sergey
Makarova, Kira S.
Semenova, Ekaterina
Minakhin, Leonid
Severinov, Konstantin
Regev, Aviv
Lander, Eric S.
Koonin, Eugene V.
Zhang, Feng
[J]. SCIENCE, 2016, 353 (6299)
[4] Biosensing with Fluorescent Carbon Nanotubes
Ackermann, Julia
Metternich, Justus T.
Herbertz, Svenja
Kruss, Sebastian
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022, 61 (18)
[5] Nanomedicine strategies to overcome the pathophysiological barriers of pancreatic cancer
Adiseshaiah, Pavan P.
Crist, Rachael M.
Hook, Sara S.
McNeil, Scott E.
[J]. NATURE REVIEWS CLINICAL ONCOLOGY, 2016, 13 (12) : 750 - 765
[6] The Augmentation of nanotechnology era: A concise review on fundamental concepts of nanotechnology and applications in material science and technology
Ahire, Satish Arvind
Bachhav, Ashwini Ashok
Pawar, Thansing Bhavsing
Jagdale, Bapu Sonu
Patil, Arun Vitthal
Koli, Prashant Bhimrao
[J]. RESULTS IN CHEMISTRY, 2022, 4
[7] Liposome mimicking polymersomes; A comparative study of the merits of polymersomes in terms of formulation and stability
Aibani, Noorjahan
Khan, Talat N.
Callan, Bridgeen
[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS-X, 2020, 2
[8] Aigner A, 2007, CURR OPIN MOL THER, V9, P345
[9] Magnetic Iron Oxide Nanoparticle (IONP) Synthesis to Applications: Present and Future
Ajinkya, Nene
Yu, Xuefeng
Kaithal, Poonam
Luo, Hongrong
Somani, Prakash
Ramakrishna, Seeram
[J]. MATERIALS, 2020, 13 (20) : 1 - 35
[10] A Comprehensive Review of Synthesis, Applications and Future Prospects for Silica Nanoparticles (SNPs)
Akhter, Faheem
Rao, Ahsan Atta
Abbasi, Mahmood Nabi
Wahocho, Shafeeque Ahmed
Mallah, Mukhtiar Ali
Anees-ur-Rehman, Hafiz
Chandio, Zubair Ahmed
[J]. SILICON, 2022, 14 (14) : 8295 - 8310

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