Mesenchymal Stem Cells in the Treatment of COVID-19

被引：9

作者：

Guo, Bei-Cyuan ^{[1
]}

Wu, Kang-Hsi ^{[2
,3
]}

Chen, Chun-Yu ^{[4
,5
]}

Lin, Wen-Ya ^{[6
]}

Chang, Yu-Jun ^{[7
]}

Lee, Tai-An ^{[8
]}

Lin, Mao-Jen ^{[9
,10
]}

Wu, Han-Ping ^{[11
,12
]}

机构：

[1] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Pediat, Tainan 70403, Taiwan

[2] Chung Shan Med Univ Hosp, Dept Pediat, Taichung 40201, Taiwan

[3] Chung Shan Med Univ, Sch Med, Taichung 40201, Taiwan

[4] Tungs Taichung Metro Harbor Hosp, Dept Emergency Med, Taichung 43503, Taiwan

[5] Jen Teh Jr Coll Med Nursing & Management, Dept Nursing, Miaoli 35664, Taiwan

[6] Taichung Vet Gen Hosp, Dept Pediat, Taichung 43503, Taiwan

[7] Changhua Christian Hosp, Lab Epidemiol & Biostast, Changhua 50006, Taiwan

[8] Chang Bing Show Chwan Mem Hosp, Dept Emergency Med, Changhua 50544, Taiwan

[9] Buddhist Tzu Chi Med Fdn, Taichung Tzu Chi Hosp, Dept Med, Div Cardiol, Taichung 42743, Taiwan

[10] Tzu Chi Univ, Coll Med, Dept Med, Hualien 97002, Taiwan

[11] Chang Gung Univ, Coll Med, Taoyuan 33302, Taiwan

[12] Chiayi Chang Gung Mem Hosp, Dept Pediat, Chiayi 61363, Taiwan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 19期

关键词：

COVID-19; mesenchymal stem cell; treatment; DISEASE; 2019; COVID-19; CORONAVIRUS DISEASE; IMMUNE-RESPONSE; INFECTION; MECHANISMS; INJURY; THROMBOCYTOPENIA; TRANSPLANTATION; LYMPHOPENIA; INVOLVEMENT;

D O I：

10.3390/ijms241914800

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Since the emergence of the coronavirus disease 2019 (COVID-19) pandemic, many lives have been tragically lost to severe infections. The COVID-19 impact extends beyond the respiratory system, affecting various organs and functions. In severe cases, it can progress to acute respiratory distress syndrome (ARDS) and multi-organ failure, often fueled by an excessive immune response known as a cytokine storm. Mesenchymal stem cells (MSCs) have considerable potential because they can mitigate inflammation, modulate immune responses, and promote tissue regeneration. Accumulating evidence underscores the efficacy and safety of MSCs in treating severe COVID-19 and ARDS. Nonetheless, critical aspects, such as optimal routes of MSC administration, appropriate dosage, treatment intervals, management of extrapulmonary complications, and potential pediatric applications, warrant further exploration. These research avenues hold promise for enriching our understanding and refining the application of MSCs in confronting the multifaceted challenges posed by COVID-19.

引用

页数：24

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