Enhancing the stability of antimicrobial peptides: From design strategies to applications

被引：35

作者：

Xu, Shenrui ^{[1
]}

Tan, Peng ^{[1
]}

Tang, Qi ^{[1
]}

Wang, Tao ^{[2
]}

Ding, Yakun ^{[3
]}

Fu, Huiyang ^{[1
]}

Zhang, Yucheng ^{[1
]}

Zhou, Chenlong ^{[1
]}

Song, Mengda ^{[3
]}

Tang, Qingsong ^{[4
]}

Sun, Zhihong

Ma, Xi ^{[1
]}

机构：

[1] China Agr Univ, Coll Anim Sci & Technol, State Key Lab Anim Nutr, Beijing 100193, Peoples R China

[2] Henan Univ Sci & Technol, Coll Anim Sci, Luoyang 471000, Henan, Peoples R China

[3] Zhengzhou Univ, Sch Agr Sci, Zhengzhou 450000, Henan, Peoples R China

[4] South West Univ, Coll Anim Sci & Technol, Chongqing 400715, Peoples R China

来源：

CHEMICAL ENGINEERING JOURNAL | 2023年 / 475卷

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

Biomaterials; Antimicrobial peptides; Stability; Structural optimization; Design strategy; PROTEOLYTIC RESISTANCE; HIGH-SELECTIVITY; SALT-RESISTANCE; AIB RESIDUES; AMINO-ACIDS; BINDING; INHIBITOR; POLYPEPTIDES; CYCLIZATION; INFECTION;

D O I：

10.1016/j.cej.2023.145923

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Antimicrobial peptides (AMPs) offer unique advantages due to their membrane-active antimicrobial mecha-nisms, which reduce the likelihood of resistance development. However, their practical application is hindered by poor stability in vivo, primarily attributed to the presence of high salt concentrations and proteases. To overcome these challenges, this review begins by summarizing the progress of AMPs in practical applications, and then focuses on introducing strategies for designing and optimizing AMPs to enhance their stability. Various approaches are discussed, including the conjugation with protease inhibitors, incorporation of cyclization or nanotechnology to constrain conformational dynamics, optimization of structural parameters of AMPs and so on. Moreover, we examine the intricate relationship between stability and design strategies. Lastly, we provide a comprehensive outlook on the future prospects and challenges in developing highly stable AMPs.

引用

页数：16

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