Manganese-Implanted Titanium Modulates the Crosstalk between Bone Marrow Mesenchymal Stem Cells and Macrophages to Improve Osteogenesis

被引：4

作者：

Ye, Kuicai ^{[1
,2
]}

Zhang, Xianming ^{[1
]}

Shangguan, Li ^{[1
,3
]}

Liu, Xingdan ^{[1
,2
]}

Nie, Xiaoshuang ^{[1
,2
]}

Qiao, Yuqin ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine M, Shanghai 200050, Peoples R China

[2] Univ Chinese Acad Sci, Ctr Mat Sci & Optoelect Engn, Beijing 100049, Peoples R China

[3] Shanghai Univ, Sch Mat Sci, Shanghai 200444, Peoples R China

来源：

JOURNAL OF FUNCTIONAL BIOMATERIALS | 2023年 / 14卷 / 09期

基金：

中国国家自然科学基金;

关键词：

manganese; plasma immersion ion implantation and deposition; crosstalk; mBMSCs; macrophages; IMMUNE CELLS; REGENERATION; COPPER; FRACTURE; ROLES;

D O I：

10.3390/jfb14090456

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Manganese (Mn) is an essential micronutrient in various physiological processes, but its functions in bone metabolism remain undefined. This is partly due to the interplay between immune and bone cells because Mn plays a central role in the immune system. In this study, we utilized the plasma immersion ion implantation and deposition (PIII & D) technique to introduce Mn onto the titanium surface. The results demonstrated that Mn-implanted surfaces stimulated the shift of macrophages toward the M1 phenotype and had minimal effects on the osteogenic differentiation of mouse bone marrow mesenchymal stem cells (mBMSCs) under mono-culture conditions. However, they promoted the M2 polarization of macrophages and improved the osteogenic activities of mBMSCs under co-culture conditions, indicating the importance of the crosstalk between mBMSCs and macrophages mediated by Mn in osteogenic activities. This study provides a positive incentive for the application of Mn in the field of osteoimmunology.

引用

页数：18

共 68 条

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