Microarchitectures of Barrett's esophagus associated with DNA methylation status

被引：2

作者：

Shijimaya, Takuya ^{[1
]}

Tahara, Tomomitsu ^{[1
]}

Yamazaki, Jumpei ^{[2
,3
,4
]}

Kobayashi, Sanshiro ^{[1
]}

Horitani, Anna ^{[1
]}

Matsumoto, Yasushi ^{[1
]}

Nakamura, Naohiro ^{[1
]}

Okazaki, Takashi ^{[1
]}

Takahashi, Yu ^{[1
]}

Tomiyama, Takashi ^{[1
]}

Honzawa, Yusuke ^{[1
]}

Fukata, Norimasa ^{[1
]}

Fukui, Toshiro ^{[1
]}

Naganuma, Makoto ^{[1
]}

机构：

[1] Kansai Med Univ, Dept Internal Med 3, Hirakata, Japan

[2] Hokkaido Univ, Vet Teaching Hosp, Grad Sch Vet Med, Translat Res Unit, Sapporo, Japan

[3] Hokkaido Univ, Hlth Res Ctr 1, Grad Sch Vet Med, Sapporo, Japan

[4] Hokkaido Univ, Vet Teaching Hosp, Grad Sch Vet Med, Sapporo, Japan

来源：

EPIGENOMICS | 2023年 / 15卷 / 15期

关键词：

Barrett's esophagus; bisulfite pyrosequencing; DNA methylation; esophageal adenocarcinoma; long-segment Barrett's esophagus; magnifying narrow-band imaging; short-segment Barrett's esophagus; MAGNIFYING ENDOSCOPY; GASTRIC-CANCER; RISK; MANAGEMENT; DIAGNOSIS; PATTERN; MARKER; SYSTEM;

D O I：

10.2217/epi-2023-0214

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Aim: DNA methylation is involved in esophageal adenocarcinoma (EAC) and Barrett's esophagus (BE). Microarchitectures of on-neoplastic BE associated with DNA methylation status were examined using magnifying narrow-band imaging (NBI) endoscopy. Patients and methods: Using biopsies from non-neoplastic BE without cancer (n = 66; N group), with EAC (n = 27; ADJ group) and EAC tissue (n = 22; T group), methylation of N33, DPYS, SLC16A12, miR124a3 and miR34bc genes were quantified. Magnifying NBI features of non-neoplastic BE were classified according to their morphologies. Results: The ADJ and T groups presented higher DNA methylation compared with the N group. Magnifying NBI endoscopic features of non-neoplastic BE also correlated with DNA methylation as an independent factor. Conclusion: Microarchitectures of BE visualized by magnifying NBI endoscopy correlated with DNA methylation.

引用

页码：759 / 767

页数：10

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