TET protein inhibitors: Potential and limitations

被引：15

作者：

Kaplanek, Robert ^{[1
,2
,3
]}

Kejik, Zdenek ^{[1
,2
,3
]}

Hajduch, Jan ^{[1
,2
,3
]}

Vesela, Katerina ^{[1
,2
,3
]}

Kucnirova, Katerina ^{[1
,2
,3
]}

Skalickova, Marketa ^{[1
,2
,3
]}

Venhauerova, Anna ^{[1
,2
,3
]}

Hosnedlova, Bozena ^{[1
,2
,3
]}

Hromadka, Robert ^{[1
,2
,3
]}

Dytrych, Petr ^{[4
,5
]}

Novotny, Petr ^{[1
,2
,3
]}

Abramenko, Nikita ^{[1
,2
,3
]}

Antonyova, Veronika ^{[1
,2
,3
]}

Hoskovec, David ^{[4
,5
]}

Babula, Petr ^{[6
]}

Masarik, Michal ^{[1
,6
,7
]}

Martasek, Pavel ^{[2
,3
]}

Jakubek, Milan ^{[1
,2
,3
]}

机构：

[1] Charles Univ Prague, Fac Med 1, BIOCEV, Prumyslova 595, Vestec 25250, Czech Republic

[2] Charles Univ Prague, Fac Med 1, Dept Paediat & Inherited Metab Disorders, Ke Karlovu 455-2, Prague 12808, Czech Republic

[3] Gen Univ Hosp Prague, Ke Karlovu 455-2, Prague 12808, Czech Republic

[4] Charles Univ Prague, Fac Med 1, Dept Surg 1, Dept Abdominal Thorac Surg & Traumatol, U Nemocnice 2, Prague 12108, Czech Republic

[5] Gen Univ Hosp, U Nemocnice 2, Prague 12108, Czech Republic

[6] Masaryk Univ, Fac Med, Dept Physiol, Kamenice 5, CZ-62500 Brno, Czech Republic

[7] Masaryk Univ, Fac Med, Dept Pathol Physiol, Kamenice 5, CZ-62500 Brno, Czech Republic

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2023年 / 166卷

关键词：

TET protein; Inhibitor; Cancer; Therapy; Mitochondria; MEDIATED 5-METHYLCYTOSINE OXIDATION; 10-11; TRANSLOCATION; DNA DEMETHYLATION; EPIGENETIC MODIFICATION; MITOCHONDRIAL-DNA; GENE-EXPRESSION; MACROPHAGE AUTOPHAGY; CHELATABLE IRON; MMP-9; PROMOTER; VALPROIC ACID;

D O I：

10.1016/j.biopha.2023.115324

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

TET proteins (methylcytosine dioxygenases) play an important role in the regulation of gene expression. Dysregulation of their activity is associated with many serious pathogenic states such as oncological diseases. Regulation of their activity by specific inhibitors could represent a promising therapeutic strategy. Therefore, this review describes various types of TET protein inhibitors in terms of their inhibitory mechanism and possible applicability. The potential and possible limitations of this approach are thoroughly discussed in the context of TET protein functionality in living systems. Furthermore, possible therapeutic strategies based on the inhibition of TET proteins are presented and evaluated, especially in the field of oncological diseases.

引用

页数：15

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