Perioperative opioids and survival outcomes in resectable head and neck cancer: A systematic review

被引:2
作者
Mastrolonardo, Eric V. [1 ]
Mann, Derek S. [1 ]
Sethi, Harleen K. [2 ]
Yun, Bo H. [1 ]
Sina, Elliott M.
Armache, Maria [4 ]
Worster, Brooke [3 ]
Fundakowski, Christopher E. [1 ]
Mady, Leila J. [4 ]
机构
[1] Thomas Jefferson Univ Hosp, Dept Otolaryngol Head & Neck Surg, Philadelphia, PA USA
[2] Philadelphia Coll Osteopath Med, Dept Otolaryngol Head & Neck Surg, Philadelphia, PA USA
[3] Thomas Jefferson Univ Hosp, Dept Hosp & Palliat Care, Philadelphia, PA USA
[4] Johns Hopkins Sch Med, Dept Otolaryngol Head & Neck Surg, 601 N Caroline St,6 Floor, Baltimore, MD 21287 USA
关键词
cancer management; clinical management; head and neck cancer; survival; INTRAOPERATIVE OPIOIDS; RECEPTOR EXPRESSION; RECURRENCE; ACTIVATION; SURGERY; GROWTH;
D O I
10.1002/cam4.6524
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
BackgroundOpioids are a mainstay in pain control for oncologic surgery. The objective of this systematic review is to evaluate the associations of perioperative opioid use with overall survival (OS) and disease-free survival (DFS) in patients with resectable head and neck cancer (HNC).MethodsA systematic review of PubMed, SCOPUS, and CINAHL between 2000 and 2022 was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies investigating perioperative opioid use for patients with HNC undergoing surgical resection and its association with OS and DFS were included.ResultsThree thousand three hundred seventy-eight studies met initial inclusion criteria, and three studies representing 562 patients (intraoperative opioids, n = 463; postoperative opioids, n = 99) met final exclusion criteria. One study identified that high intraoperative opioid requirement in oral cancer surgery was associated with decreased OS (HR = 1.77, 95% CI 0.995-3.149) but was not an independent predictor of decreased DFS. Another study found that increased intraoperative opioid requirements in treating laryngeal cancer was demonstrated to have a weak but statistically significant inverse relationship with DFS (HR = 1.001, p = 0.02) and OS (HR = 1.001, p = 0.02). The last study identified that patients with chronic opioid after resection of oral cavity cancer had decreased DFS (HR = 2.7, 95% CI 1.1-6.6) compared to those who were not chronically using opioids postoperatively.ConclusionAn association may exist between perioperative opioid use and OS and DFS in patients with resectable HNC. Additional investigation is required to further delineate this relationship and promote appropriate stewardship of opioid use with adjunctive nonopioid analgesic regimens.
引用
收藏
页码:18882 / 18888
页数:7
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