Mechanical Properties of Alginate Hydrogels Cross-Linked with Multivalent Cations

被引:86
作者
Malektaj, Haniyeh [1 ]
Drozdov, Aleksey D. [1 ]
Christiansen, Jesper deClaville [1 ]
机构
[1] Aalborg Univ, Dept Mat & Prod, Fibigerstr 16, DK-9220 Aalborg, Denmark
关键词
alginate; hydrogel; multivalent cations; mechanical properties; equilibrium swelling; DRUG-DELIVERY; PHYSICOCHEMICAL PROPERTIES; STRONTIUM; GEL; SCAFFOLDS; GELATION; PROGRESS; IONS;
D O I
10.3390/polym15143012
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Ionically, cross-linked alginate gels have a potential to be used in a wide range of biomedical, environmental and catalytic applications. The study deals with preparation of alginate hydrogels cross-linked with various cations and the analysis of their equilibrium swelling and mechanical properties. It is shown that the type of cations used in the cross-linking process affects the elastic moduli and the equilibrium degree of swelling of the gels. The experimental data in small-amplitude oscillatory tests are fitted with a model that involves two material parameters: the elastic modulus of a polymer network and a measure of its inhomogeneity. The influence of cations on these quantities is studied numerically. It is revealed that the dependence of the elastic modulus of ionically cross-linked alginate gels on their equilibrium degree of swelling differs from that predicted by the conventional theory for covalently cross-linked gels.
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页数:11
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