Enhanced IgG immune response to COVID-19 vaccination in patients with sickle cell disease

被引：7

作者：

Nakahara, Hirotomo ^{[1
,2
]}

Cheedarla, Narayanaiah ^{[2
]}

Verkerke, Hans P. ^{[2
]}

Cheedarla, Suneethamma ^{[2
]}

Wu, Shang-Chuen ^{[3
]}

Hendrickson, Jeanne E. ^{[1
,2
,4
]}

Chang, Andres

McLemore, Morgan L.

El Rassi, Fuad

Roback, John D. ^{[1
,2
]}

Neish, Andrew S. ^{[2
,5
]}

Fasano, Ross M. ^{[1
,2
,5
,6
]}

Stowell, Sean R. ^{[3
,5
]}

机构：

[1] Emory Univ, Ctr Transfus Med & Cellular Therapies, Sch Med, Atlanta, GA USA

[2] Emory Univ, Dept Pathol & Lab Med, Sch Med, Atlanta, GA USA

[3] Harvard Med Sch, Brigham & Womens Hosp, Joint Program Transfus Med, Boston, MA 02115 USA

[4] Yale Sch Med, Dept Lab Med, New Haven, CT USA

[5] Emory Univ, Winship Canc Inst, Dept Hematol & Med Oncol, Sch Med, Atlanta, GA USA

[6] Emory Univ, Dept Pathol & Lab Med, Hematol, Sch Med, Atlanta, GA 30322 USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2023年

基金：

美国国家卫生研究院;

关键词：

antibodies; haemoglobinopathies; immunology; sickle cell anaemia; sickle cell disease; vaccines;

D O I：

10.1111/bjh.18899

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Patients with sickle cell disease (SCD) are considered to be immunocompromised, yet data on the antibody response to SARS-CoV-2 vaccination in SCD is limited. We investigated anti-SARS-CoV-2 IgG titres and overall neutralizing activity in 201 adults with SCD and demographically matched non-SCD controls. Unexpectedly, patients with SCD generate a more robust and durable COVID-19 vaccine IgG response compared to matched controls, though the neutralizing activity remained similar across both cohorts. These findings suggest that patients with SCD achieve a similar antibody response following COVID-19 vaccination compared to the general population, with implications for optimal vaccination strategies for patients with SCD.

引用

页码：937 / 941

页数：5

共 15 条

[1] Innate immune cells, major protagonists of sickle cell disease pathophysiology [J].

Allali, Slimane ;

Maciel, Thiago Trovati ;

Hermine, Olivier ;

de Montalembert, Mariane .

HAEMATOLOGICA, 2020, 105 (02) :273-283

[2] The Development and Consequences of Red Blood Cell Alloimmunization [J].

Arthur, Connie M. ;

Stowell, Sean R. .

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE, 2023, 18 :537-564

[3] Alteration of lymphocyte phenotype and function in sickle cell anemia: Implications for vaccine responses [J].

Balandya, Emmanuel ;

Reynolds, Teri ;

Obaro, Stephen ;

Makani, Julie .

AMERICAN JOURNAL OF HEMATOLOGY, 2016, 91 (09) :938-946

[4] Humoral Responses Against SARS-CoV-2 and Variants of Concern After mRNA Vaccines in Patients With Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia [J].

Chang, Andres ;

Akhtar, Akil ;

Linderman, Susanne L. ;

Lai, Lilin ;

Orellana-Noia, Victor M. ;

Valanparambil, Rajesh ;

Ahmed, Hasan ;

Zarnitsyna, Veronika, I ;

McCook-Veal, Ashley A. ;

Switchenko, Jeffrey M. ;

Koff, Jean L. ;

Blum, Kristie A. ;

Ayers, Amy A. ;

O'Leary, Colin B. ;

Churnetski, Michael C. ;

Sulaiman, Shahana ;

Kives, Melissa ;

Sheng, Preston ;

Davis, Carl W. ;

Nooka, Ajay K. ;

Antia, Rustom ;

Dhodapkar, Madhav, V ;

Suthar, Mehul S. ;

Cohen, Jonathon B. ;

Ahmed, Rafi .

JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (26) :3020-+

[5]

Cheedarla N., 2022, PREPRINT, DOI [10.21203/rs.3.rs-1322411/v1, DOI 10.21203/RS.3.RS-1322411/V1]

[6] COVID19 vaccination in adults with sickle cell disease is not associated with increases in rates of pain crisis [J].

Friedman, Elana ;

Minniti, Caterina ;

Campbell, Sean ;

Curtis, Susanna .

HEMATOLOGY, 2022, 27 (01) :742-744

[7] Quantitative analysis of mRNA-1273 COVID-19 vaccination response in immunocompromised adult hematology patients [J].

Haggenburg, Sabine ;

Lissenberg-Witte, Birgit, I ;

van Binnendijk, Rob S. ;

den Hartog, Gerco ;

Bhoekhan, Michel S. ;

Haverkate, Nienke J. E. ;

de Rooij, Dennis M. ;

van Meerloo, Johan ;

Cloos, Jacqueline ;

Kootstra, Neeltje A. ;

Wouters, Dorine ;

Weijers, Suzanne S. ;

van Leeuwen, Ester M. M. ;

Bontkes, Hetty J. ;

Tonouh-Aajoud, Saida ;

Heemskerk, Mirjam H. M. ;

Sanders, Rogier W. ;

Roelandse-Koop, Elianne ;

Hofsink, Quincy ;

Groen, Kazimierz ;

Cetinel, Lucia ;

Schellekens, Louis ;

den Hartog, Yvonne M. ;

Toussaint, Belle ;

Kant, Iris M. J. ;

Graas, Thecla ;

de Pater, Emma ;

Dik, Willem A. ;

Engel, Marije D. ;

Pierie, Cheyenne R. N. ;

Janssen, Suzanne R. ;

van Dijkman, Edith ;

Poniman, Meliawati ;

Burger, Judith A. ;

Bouhuijs, Joey H. ;

Smits, Gaby ;

Rots, Nynke Y. ;

Zweegman, Sonja ;

Kater, Arnon P. ;

van Meerten, Tom ;

Mutsaers, Pim G. N. J. ;

van Doesum, Jaap A. ;

Broers, Annoek E. C. ;

van Gils, Marit J. ;

Goorhuis, Abraham ;

Rutten, Caroline E. ;

Hazenberg, Mette D. ;

Nijhof, Inger S. .

BLOOD ADVANCES, 2022, 6 (05) :1537-1546

[8] COVID-19 vaccination status and disease burden in patients with sickle cell disease [J].

Han, Jin ;

Zhang, Xu ;

Molokie, Robert E. ;

Njoku, Franklin U. ;

Hussain, Faiz A. ;

Farooqui, Marwah ;

Rizvi, Insia ;

Saraf, Santosh L. ;

Gordeuk, Victor R. .

BRITISH JOURNAL OF HAEMATOLOGY, 2022, 199 (04) :E21-E24

[9] Clinical outcomes of COVID-19 in patients with sickle cell disease and sickle cell trait: A critical appraisal of the literature [J].

Hoogenboom, Wouter S. ;

Alamuri, Tharun T. ;

McMahon, Daniel M. ;

Balanchivadze, Nino ;

Dabak, Vrushali ;

Mitchell, William B. ;

Morrone, Kerry B. ;

Manwani, Deepa ;

Duong, Tim Q. .

BLOOD REVIEWS, 2022, 53

[10] Safety of coronavirus disease 2019 vaccines in 213 adult patients with sickle cell disease [J].

Joseph, Laure ;

Corbasson, Anne ;

Manceau, Sandra ;

Khimoud, Djamal ;

Meunier, Benoit ;

Cheminet, Geoffrey ;

Lefrere, Francois ;

Jannot, Anne-Sophie ;

Lu, Estelle ;

Arlet, Jean-Benoit .

BRITISH JOURNAL OF HAEMATOLOGY, 2023, 200 (05) :563-567

← 1 2 →