Maternal Hypertension and Early-Onset Neonatal Neutropenia

被引：0
|
作者：
Joslyn, Peter [1 ,3 ]
Oral, Evrim [2 ]
Martin, Anne [1 ]
Surcouf, Jeffrey [1 ]
Barkemeyer, Brian [1 ]
机构：
[1] Louisiana State Univ, Dept Pediat, Hlth Sci Ctr New Orleans, New Orleans, LA USA
[2] Louisiana State Univ, Sch Publ Hlth, Biostat Program, Hlth Sci Ctr New Orleans, New Orleans, LA USA
[3] Louisiana State Univ, Dept Pediat, Div Neonatol, Hlth Sci Ctr New Orleans, 200 Henry Clay Ave, New Orleans, LA 70118 USA
来源：
FETAL AND PEDIATRIC PATHOLOGY | 2023年 / 42卷 / 05期
关键词：
Preeclampsia; hypertension; neutropenia; neonate; very low birthweight infants; NOSOCOMIAL INFECTION; WEIGHT; BIRTH; COUNT; BLOOD; RISK; MANIFESTATIONS; INFANTS; SEPSIS; HEALTH;
D O I：
10.1080/15513815.2023.2220406
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Objective: Maternal hypertension is considered a risk factor for early neonatal neutropenia. We sought to explore this relationship. Study Design: This retrospective cohort study compared initial neutrophil counts in infants born to mothers with preeclampsia with severe features (PSF) and infants born to normotensive mothers using Negative Binomial Regression (NBR) and logistic regression models. Results: Maternal hypertension negatively affected the early neonatal neutrophil count (adjusted NRB coefficient 0.4 [0.2, 0.6], p < 0.0001) but did not increase the risk of neutropenia (OR 2.07 [0.97, 4.41], p = 0.06). The initial neutrophil count and neutropenia risk were not different between PSF subgroups. Gestational age had the greatest impact on neutropenia risk (OR 0.72 [0.64, 0.81], p < 0.0001). Almost all neutropenia resolved within 48 h. Conclusion: Maternal hypertension negatively affects the early neonatal neutrophil count while not increasing the risk of neonatal neutropenia.
引用
收藏
页码：735 / 745
页数：11
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