Group 2 innate lymphoid cells and their surrounding environment

被引：8

作者：

Naito, Maiko ^{[1
,2
]}

Kumanogoh, Atsushi ^{[1
,2
,3
,4
,5
,6
]}

机构：

[1] Osaka Univ, Grad Sch Med, Dept Resp Med & Clin Immunol, Suita, Osaka, Japan

[2] Osaka Univ, World Premier Int Res Ctr Initiat WPI, Immunol Frontier Res Ctr IFReC, Dept Immunopathol, Suita, Osaka, Japan

[3] Osaka Univ, Inst Open & Transdisciplinary Res Initiat OTRI, Integrated Frontier Res Med Sci Div, Suita, Osaka, Japan

[4] Osaka Univ, Ctr Infect Dis Educ & Res CiDER, Suita, Osaka, Japan

[5] Osaka Univ, Japan Agcy Med Res & Dev Core Res Evolut Sci & Tec, Suita, Osaka, Japan

[6] Osaka Univ, Ctr Adv Modal & DDS CAMaD, Suita, Osaka, Japan

来源：

INFLAMMATION AND REGENERATION | 2023年 / 43卷 / 01期

基金：

日本学术振兴会;

关键词：

Adventitial stromal cell (ASC); Group 2 innate lymphoid cell (ILC2); Mesenchymal cells; Microenvironment; THYMIC STROMAL LYMPHOPOIETIN; NEUROMEDIN-U; ASTHMATIC AIRWAYS; TYPE-2; RECEPTOR; EXPRESSION; INFLAMMATION; INDUCTION; BLOOD; IDENTIFICATION;

D O I：

10.1186/s41232-023-00272-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Since the discovery of group 2 innate lymphoid cells (ILC2s) in 2010, subsequent studies have revealed their developmental pathways, mechanisms of activation and regulation, and immunological roles in tissue homeostasis and tissue-specific diseases in various organs. Although ILC2s are known to express tissue-specific features depending on where they reside, how the surrounding environment affects the functions of ILC2s remains to be fully elucidated. Recent histologic analyses revealed that ILC2s resides in specific perivascular regions in peripheral tissues with their function being controlled by the surrounding cells via cytokines, lipid mediators, neurotransmitters, and cell-cell interactions through surface molecules. This review summarizes the interactions between ILC2s and surrounding cells, including epithelial cells, neurons, immune cells, and mesenchymal cells, with the objective of promoting the development of novel diagnostic and therapeutic methods for ILC2-related diseases.

引用

页数：10

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