Bismuth-catalyzed arylation of ethyl glyoxylate with aniline via N-H insertion

被引：0

作者：

Bin Riyaz, Mohd Aamir ^{[1
]}

Premkumar, G. ^{[1
]}

Swu, Toka ^{[1
]}

机构：

[1] Pondicherry Univ, Dept Chem, Kalapet 605014, Puducherry, India

来源：

MOLECULAR DIVERSITY | 2023年 / 27卷 / 01期

关键词：

Bismuth chloride; N-H insertion; Aniline; Ethylglyoxylate; DIAZO-COMPOUNDS; HETEROCYCLIC CARBENE; EFFICIENT; NITROGEN; BONDS; PORPHYRINS; CORROLES;

D O I：

10.1007/s11030-022-10411-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glycine derivatives such as ethyl 2-(4-aminophenyl)-2-(phenylamino) acetate is an exciting and essential non-proteinogenic class of amino acids. Herein, we report an efficient and novel route to synthesize glycine derivatives using ethyl glyoxylate, aniline, and its derivatives catalyzed by bismuth salts. In our scheme, mild, non-toxic, and commercially viable reagents were utilized. The synthesized moieties were characterized by ESI-MASS, H-1-NMR, C-13-NMR, and XRD techniques. The target glycine derivatives were successfully obtained with a maximum yield of 87%. Moreover, the reaction is very green as water is the only byproduct. [GRAPHICS] .

引用

页码：167 / 175

页数：9

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