Evaluation of bone repair with platelet-rich fibrin following the extraction of impacted third molars - randomized clinical trial

Background: The aim of the present study was to evaluate postoperative effects of platelet-rich fibrin (PRF) in wound and bone healing, pain, swelling and periodontal complications outcomes after impacted third molars extraction. Material and Methods: A prospective, randomized, split-mouth, double-blind clinical trial was conducted. PRF was placed within sockets following tooth removal and before suturing mucoperiosteal flap while no treatment was performed on control group's sockets. Patients were evaluated considering bone volume which was obtained in the 90-day postoperative period. Other variables included trabecular thickness, trabecular distance and grey values, pain, swelling, and wound healing. A Wilcoxon test and a t-Student test were used at a 5% significance level and a Friedman test was used to multiple comparisons. Results: Forty-four surgeries were performed in the present study. The patients' mean age was 22.41 (+/- 2.75 years) and 72.73% were women. PRF was associated to increased trabecular thickness and bone volume means ( p < 0.001). The experimental group had significantly lower pain scores at 4h, 6h, 8h, 16h, 24h, and 72h ( p < 0.05). Mean swelling was lower on the experimental group ( p < 0.001). The PRF group showed significant higher wound healing ( p < 0.001). Conclusions: Alveolar filling with PRF improves wound and bone healing after extractions while also decreasing pain and swelling in the postoperative period.