Case report: Life threatening hyponatremia in infants with urinary tract infections: two cases of type III pseudohypoaldosteronism and review of the literature

被引：1

作者：

Carl, Cecile ^{[1
,2
]}

Dinkelbach, Lars ^{[1
,3
]}

Mohr, Julia ^{[1
]}

Perez, Ruy ^{[1
]}

Vera Lopez, Tobias ^{[1
]}

Fricke-Otto, Susanne ^{[1
]}

Niehues, Tim ^{[1
]}

机构：

[1] HELIOS Klinikum Krefeld, Ctr Child & Adolescent Hlth, Krefeld, Germany

[2] Rhein Westfal TH Aachen, Med Fac, Aachen, Germany

[3] Univ Duisburg Essen, Univ Childrens Hosp Essen, Dept Pediat 3, Essen, Germany

来源：

FRONTIERS IN PEDIATRICS | 2024年 / 11卷

关键词：

pseudohypoaldosteronism; hyponatremia; hyperkalemia; urinary tract infections; hydronephrosis; congenital anomalies of the kidney and urinary tract; TRANSIENT PSEUDOHYPOALDOSTERONISM; SECONDARY; HYPERKALEMIA; MECHANISMS; DIAGNOSIS;

D O I：

10.3389/fped.2023.1233205

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We describe two female infants at the age of five and six months with urinary tract infections presenting with vomiting and reduced drinking behavior. On laboratory analysis, severe hyponatremia (106 mmol/L and 109 mmol/L) was seen with hyperkalemia and compensated metabolic acidosis. Endocrinological analyses revealed massively increased levels of aldosterone and renin, leading to the diagnosis of type III pseudohypoaldosteronism (PHA). A review of the current literature 2013-2023 revealed 26 type III PHA cases aged up to ten months with reduced drinking behavior, weight loss and/or failure to thrive being the most common clinical presentations. Given the severe presentation of PHA electrolyte measurements in infants with urinary tract infections and/or in infants with congenital anomalies of the kidney and urinary tract (CAKUT) are strongly recommended.

引用

页数：10