Targeted Therapy of Spinal Cord Injury: Inhibition of Apoptosis Is a Promising Therapeutic Strategy

被引：13
作者：
He, Wei [1 ,2 ,3 ]
Li, Zhi-qiang [1 ,2 ,3 ]
Gu, Hou-yun [1 ,2 ,3 ]
Pan, Qi-lin [1 ,2 ,3 ]
Lin, Fei-xiang [1 ,2 ,3 ]
机构：
[1] Ganzhou Peoples Hosp, Dept Spine Surg, 16 Meiguan Ave, Ganzhou 341000, Jiangxi, Peoples R China
[2] Nanchang Univ, Affiliated Ganzhou Hosp, Dept Spine Surg, 16 Meiguan Ave, Ganzhou 341000, Jiangxi, Peoples R China
[3] Southern Med Univ, Ganzhou Hosp, Nanfang Hosp, 16 Meiguan Ave, Ganzhou 341000, Jiangxi, Peoples R China
来源：
MOLECULAR NEUROBIOLOGY | 2024年 / 61卷 / 07期
关键词：
Spinal cord injury (SCI); Secondary injury; Apoptosis; Signaling pathway; Targeted therapy; NF-KAPPA-B; IMPROVES FUNCTIONAL RECOVERY; PROGRAMMED CELL-DEATH; TNF-ALPHA; REGULATING AUTOPHAGY; REDUCES APOPTOSIS; PROMOTES RECOVERY; SIGNALING PATHWAY; PI3K/AKT PATHWAY; NONCODING RNAS;
D O I：
10.1007/s12035-023-03814-w
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Spinal cord injury (SCI) is a serious disabling central nervous system injury that can lead to motor, sensory, and autonomic dysfunction below the injury level. SCI can be divided into primary injury and secondary injury according to pathological process. Primary injury is mostly irreversible, while secondary injury is a dynamic regulatory process. Apoptosis is an important pathological event of secondary injury and has a significant effect on the recovery of nerve function after SCI. Nerve cell death can further aggravate the microenvironment of the injured site, leading to neurological dysfunction and thus affect the clinical outcome of patients. Therefore, apoptosis plays a crucial role in the pathological progression of secondary SCI, while inhibiting apoptosis may be a promising therapeutic strategy for SCI. This review will summarize and explore the factors that lead to cell death after SCI, the influence of cross talk between signaling pathways and pathways involved in apoptosis and discuss the influence of apoptosis on SCI, and the therapeutic significance of targeting apoptosis on SCI. This review helps us to understand the role of apoptosis in secondary SCI and provides a theoretical basis for the treatment of SCI based on apoptosis.
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收藏
页码：4222 / 4239
页数：18
相关论文
共 218 条
[1]  
Amini Pishva Akram, 2016, Acta Med Iran, V54, P296
[2]   Inflammogenesis of Secondary Spinal Cord Injury [J].
Anwar, M. Akhtar ;
Al Shehabi, Tuqa S. ;
Eid, Ali H. .
FRONTIERS IN CELLULAR NEUROSCIENCE, 2016, 10
[3]   Interplay between MAPK/ERK signaling pathway and MicroRNAs: A crucial mechanism regulating cancer cell metabolism and tumor progression [J].
Asl, Elmira Roshani ;
Amini, Mohammad ;
Najafi, Souzan ;
Mansoori, Behzad ;
Mokhtarzadeh, Ahad ;
Mohammadi, Ali ;
Lotfinejad, Parisa ;
Bagheri, Mehdi ;
Shirjang, Solmaz ;
Lotfi, Ziba ;
Rasmi, Yousef ;
Baradaran, Behzad .
LIFE SCIENCES, 2021, 278
[4]  
Awane M, 1999, J IMMUNOL, V162, P5337
[5]   Inflammation, degeneration and regeneration in the injured spinal cord: insights from DNA microarrays [J].
Bareyre, FM ;
Schwab, ME .
TRENDS IN NEUROSCIENCES, 2003, 26 (10) :555-563
[6]   Cytotoxic T lymphocytes: All roads lead to death [J].
Barry, M ;
Bleackley, RC .
NATURE REVIEWS IMMUNOLOGY, 2002, 2 (06) :401-409
[7]   Neuroprotective action of resveratrol [J].
Bastianetto, Stephane ;
Menard, Caroline ;
Quirion, Remi .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2015, 1852 (06) :1195-1201
[8]  
Beattie MS, 2002, PROG BRAIN RES, V137, P37
[9]   Review of current evidence for apoptosis after spinal cord injury [J].
Beattie, MS ;
Farooqui, AA ;
Bresnahan, JC .
JOURNAL OF NEUROTRAUMA, 2000, 17 (10) :915-925
[10]   CXCR4-activated astrocyte glutamate release via TNFa: amplification by microglia triggers neurotoxicity [J].
Bezzi, P ;
Domercq, M ;
Brambilla, L ;
Galli, R ;
Schols, D ;
De Clercq, E ;
Vescovi, A ;
Bagetta, G ;
Kollias, G ;
Meldolesi, J ;
Volterra, A .
NATURE NEUROSCIENCE, 2001, 4 (07) :702-710
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