The TMEM16A anion channel as a versatile regulator of vascular tone

被引：1
|
作者：
Tammaro, Paolo [1 ]
机构：
[1] Univ Oxford, Dept Pharmacol, Mansfield Rd, Oxford OX1 3QT, England
来源：
SCIENCE SIGNALING | 2023年 / 16卷 / 811期
基金：
英国生物技术与生命科学研究理事会; 英国医学研究理事会;
关键词：
D O I：
10.1126/scisignal.adk5661
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The TMEM16A channel represents a key depolarizing mechanism in arterial smooth muscle and contractile pericytes, where it is activated by several endogenous contractile agonists. In this issue of Science Signaling, Mata-Daboin et al. demonstrate a previously unidentified role for TMEM16A in endothelial cells for acetylcholine-mediated vasorelaxation. Collectively, TMEM16A serves as a transducer of vasoactive stimuli to enable fine modulation of vessel tone.
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页数：3
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