Addicted to proteostasis: How KRAS-driven cancers acquire resistance to clinical KRAS inhibitors

被引：0
|
作者：
Klein, Austin T. [1 ,2 ,3 ]
Mendillo, Marc L. [1 ,2 ,3 ]
机构：
[1] Northwestern Univ, Feinberg Sch Med, Dept Biochem & Mol Genet, Chicago, IL 60611 USA
[2] Northwestern Univ, Simpson Querrey Ctr Epigenet, Feinberg Sch Med, Chicago, IL 60611 USA
[3] Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, Feinberg Sch Med, Chicago, IL 60611 USA
来源：
CELL CHEMICAL BIOLOGY | 2023年 / 30卷 / 11期
关键词：
D O I：
10.1016/j.chembiol.2023.10.007
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The development of KRAS inhibitors was a remarkable feat, yet their efficacy is limited by inevitable resis-tance. In the September issue of Science, Lv et al.1 demonstrate how KRAS-driven cancers rewire signaling to restore protein homeostasis and acquire resistance to KRAS inhibitors with implications for novel combi-nation therapeutic strategies.
引用
收藏
页码：1334 / 1336
页数：3
相关论文
共 50 条
  • [1] SPARK, studying pathways of resistance in KRAS-driven cancers: A remote plasma ctDNA participation study to identify mechanisms of resistance to KRAS inhibitors
    Ricciuti, Biagio
    Lee, Elinton
    Conneran, Terri
    King, Jennifer C.
    Harper, Allison
    Lamberti, Giuseppe
    Brisbane, Gifty
    Hoskova, Katerina
    Clifford, Sarah
    Murphy, Jo-Ellen
    Huang, Richard S. P.
    Oxnard, Geoffrey R.
    Addario, Anthony
    Erwin, Richard M.
    Tolba, Khaled
    Awad, Mark M.
    JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)
  • [2] Small-Molecule Inhibitors and Degraders Targeting KRAS-Driven Cancers
    Hyun, Soonsil
    Shin, Dongyun
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (22)
  • [3] Cancer vaccines: Targeting KRAS-driven cancers
    Zhang, Ying
    Ma, Jin-An
    Zhang, Hai-Xia
    Jiang, Yu-Na
    Luo, Wen-Hao
    EXPERT REVIEW OF VACCINES, 2020, 19 (02) : 163 - 173
  • [4] Developing combinatorial therapies for KRAS-driven cancers
    Cichowski, Karen
    MOLECULAR CANCER RESEARCH, 2023, 21 (05)
  • [5] A synergistic combination therapy for KRAS-driven cancers
    Yang, Z.
    Liang, S-Q.
    Peng, R-W.
    Schmid, R. A.
    JOURNAL OF THORACIC ONCOLOGY, 2021, 16 (04) : S706 - S706
  • [6] Targeting metabolic reprogramming in KRAS-driven cancers
    Kenji Kawada
    Kosuke Toda
    Yoshiharu Sakai
    International Journal of Clinical Oncology, 2017, 22 : 651 - 659
  • [7] Targeting metabolic reprogramming in KRAS-driven cancers
    Kawada, Kenji
    Toda, Kosuke
    Sakai, Yoshiharu
    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 2017, 22 (04) : 651 - 659
  • [8] KRAS-Driven Tumorigenesis and KRAS-Driven Therapy in Pancreatic Adenocarcinoma
    Than, Minh T.
    O'Hara, Mark
    Stanger, Ben Z.
    Reiss, Kim A.
    MOLECULAR CANCER THERAPEUTICS, 2024, 23 (10) : 1378 - 1388
  • [9] Decoding the proteostasis network in resistance to KRAS inhibitors
    Song, Xinxin
    Zhou, Zhuan
    Westover, Kenneth D.
    INNOVATION, 2023, 4 (06):
  • [10] Behind the Wheel of Epithelial Plasticity in KRAS-Driven Cancers
    Arner, Emily N.
    Du, Wenting
    Brekken, Rolf A.
    FRONTIERS IN ONCOLOGY, 2019, 9
12345