Design of gefitinib-loaded PLGA microspheres via microfluidics for lung cancer

被引:8
作者
Huang, Ruohan [1 ]
Zhang, Hui [2 ]
Lv, Lulu [1 ]
Zhang, Yuqi [1 ]
Li, Jun [1 ,5 ]
Wang, Huan [3 ,4 ]
Gao, Wen [1 ,5 ]
机构
[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Oncol, 300 Guangzhou Rd, Nanjing 210029, Peoples R China
[2] Southeast Univ, Zhongda Hosp, Dept Otolaryngol Head & Neck Surg, Sch Life Sci,State Key Lab Digital Med Engn,Jiangs, Nanjing 210096, Peoples R China
[3] Sun Yat Sen Univ, Affiliated Hosp 8, Shenzhen 518033, Peoples R China
[4] Shenzhen Univ, Sch Med, Dept Biomed Engn, Guangdong Key Lab Biomed Measurements & Ultrasound, Shenzhen, Peoples R China
[5] Nanjing Med Univ, Affiliated Hosp 1, 300 Guangzhou Rd, Nanjing 210029, Peoples R China
基金
中国国家自然科学基金;
关键词
Microfluidics; Gefitinib; Targeted therapy; Sustained release; PLGA; ELECTROSPRAY; STATISTICS; PARTICLES; CHINA;
D O I
10.1016/j.matdes.2023.112336
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
Lung cancer is one of the most prevalent tumors with rapid progression and poor prognosis, which badly affects human physical and mental health. Although traditional anti-cancer therapies, such as chemotherapy and radiation, have demonstrated some degree of effectiveness in treating tumors, they remain encumbered by the frequent, uncontrollable, and large dosage of drug administration. Here, we introduced the Gefitinib-loaded PLGA microspheres generated from microfluidics for lung cancer therapy. The microspheres had a homogeneous shape and a high drug loading rate. Studies have shown that PLGA microspheres not only provided greater loading efficiency and sustained release of gefitinib but also protected the drug from rapid breakdown. The results of animal experiments also showed that the drug-loaded microspheres could achieve or even outperform the efficiency of daily medication with less frequency. Therefore, it is foreseen that PLGA microspheres will have great potential in developing therapies for lung cancer.
引用
收藏
页数:8
相关论文
共 77 条
  • [1] Long-acting injectable PLGA/PLA depots for leuprolide acetate: successful translation from bench to clinic
    Abulateefeh, Samer R.
    [J]. DRUG DELIVERY AND TRANSLATIONAL RESEARCH, 2023, 13 (02) : 520 - 530
  • [2] Recent progress and challenges for polymeric microsphere compared to nanosphere drug release systems: Is there a real difference?
    Alavi, Mehran
    Webster, Thomas J.
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 33
  • [3] Roe-inspired stem cell microcapsules for inflammatory bowel disease treatment
    Chen, Guopu
    Wang, Fengyuan
    Nie, Min
    Zhang, Hui
    Zhang, Han
    Zhao, Yuanjin
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 118 (43)
  • [4] Microfluidic Electrospray Niacin Metal-Organic Frameworks Encapsulated Microcapsules for Wound Healing
    Chen, Guopu
    Yu, Yunru
    Wu, Xiuwen
    Wang, Gefei
    Gu, Guosheng
    Wang, Feng
    Ren, Jianan
    Zhang, Huidan
    Zhao, Yuanjin
    [J]. RESEARCH, 2019, 2019
  • [5] Effect of Particle Size on Drug Loading and Release Kinetics of Gefitinib-Loaded PLGA Microspheres
    Chen, Weiluan
    Palazzo, Amelia
    Hennink, Wim E.
    Kok, Robbert J.
    [J]. MOLECULAR PHARMACEUTICS, 2017, 14 (02) : 459 - 467
  • [6] Artificial Spider Silk Based Programmable Woven Textile for Efficient Wound Management
    Cheng, Cheng
    Qiu, Yumeng
    Tang, Shimeng
    Lin, Baoyang
    Guo, Maoze
    Gao, Bingbing
    He, Bingfang
    [J]. ADVANCED FUNCTIONAL MATERIALS, 2022, 32 (06)
  • [7] Poly(ester-thioether) microspheres co-loaded with erlotinib and α-tocopheryl succinate for combinational therapy of non-small cell lung cancer
    Cheng, Furong
    Peng, Xinyu
    Meng, Guolong
    Pu, Yuji
    Luo, Kui
    He, Bin
    [J]. JOURNAL OF MATERIALS CHEMISTRY B, 2020, 8 (08) : 1728 - 1738
  • [8] Droplet Microfluidics for Tumor Drug-Related Studies and Programmable Artificial Cells
    Dimitriou, Pantelitsa
    Li, Jin
    Tornillo, Giusy
    McCloy, Thomas
    Barrow, David
    [J]. GLOBAL CHALLENGES, 2021, 5 (07)
  • [9] Recent advances of PLGA micro/nanoparticles for the delivery of biomacromolecular therapeutics
    Ding, Dawei
    Zhu, Qingdi
    [J]. MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2018, 92 : 1041 - 1060
  • [10] Escareño N, 2021, J COLLOID INTERF SCI, V591, P440, DOI 10.1016/j.jcis.2021.02.031