Effects of clinical medications on male fertility and prospects for stem cell therapy

被引：1
作者：
Mo, Peiting [1 ]
Zhao, Ziran [1 ]
Ke, Xinpeng [1 ]
Fan, Yong [1 ]
Li, Chaohui [1 ]
机构：
[1] Guangzhou Med Univ, Guangdong Higher Educ Inst, Dept Obstet & Gynecol,Key Lab Reprod & Genet, Key Lab Major Obstet Dis Guangdong Prov,Affiliated, Guangzhou, Guangdong, Peoples R China
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2023年 / 11卷
基金：
中国国家自然科学基金;
关键词：
male fertility; clinical medications; spermatogenesis; stem cell therapy; exosomes therapy; ANGIOTENSIN-CONVERTING ENZYME; CALCIUM-CHANNEL BLOCKERS; LONG-TERM TREATMENT; HIGH-FAT DIET; OXIDATIVE STRESS; MALE RATS; TESTICULAR TISSUE; VALPROIC ACID; GERM-CELLS; SEXUAL FUNCTION;
D O I：
10.3389/fcell.2023.1258574
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
An increasing number of men require long-term drug therapy for various diseases. However, the effects of long-term drug therapy on male fertility are often not well evaluated in clinical practice. Meanwhile, the development of stem cell therapy and exosomes treatment methods may provide a new sight on treating male infertility. This article reviews the influence and mechanism of small molecule medications on male fertility, as well as progress of stem cell and exosomes therapy for male infertility with the purpose on providing suggestions (recommendations) for evaluating the effect of drugs on male fertility (both positive and negative effect on male fertility) in clinical application and providing strategies for diagnosis and treatment of male infertility.
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页数：19
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