Association of leadless pacing with ventricular and valvular function

被引:6
作者
Arps, Kelly [1 ]
Li, Bicong [1 ]
Allen, John Carson, Jr. [1 ]
Alenezi, Fawaz [1 ]
Frazier-Mills, Camille [1 ]
Al-Khatib, Sana M. [1 ]
Jackson, Kevin P. [1 ]
Jackson II, Larry R. [1 ]
Thomas, Kevin L. [1 ]
Piccini, Jonathan P. [1 ]
机构
[1] Duke Univ, Med Ctr, Div Cardiovasc Dis, Sect Cardiac Electrophysiol, DUMC 7451,2301 Erwin Rd, Durham, NC 27710 USA
关键词
leadless pacemaker; LVEF; TAPSE; tricuspid regurgitation; TRICUSPID-VALVE REGURGITATION; PACEMAKER; PREDICTORS; DEFIBRILLATOR; IMPLANTATION;
D O I
10.1111/jce.16046
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
BackgroundTraditional transvenous pacemakers are associated with worsening tricuspid valve function due to lead-related leaflet impingement, as well as ventricular dysfunction related to electromechanical dyssynchrony from chronic right ventricular (RV) pacing. The association of leadless pacing with ventricular and valvular function has not been well established. We aimed to assess the association of leadless pacemaker placement with changes in valvular regurgitation and ventricular function.Methods and ResultsEchocardiographic features before and after leadless pacemaker implant were analyzed in consecutive patients who received a leadless pacemaker with pre- and postprocedure echocardiography at Duke University Hospital between November 2014 and November 2019. Valvular regurgitation was graded ordinally from 0 (none) to 3 (severe). Among 54 patients, the mean age was mean age was 70.1 & PLUSMN; 14.3 years, 24 (44%) were women, and the most frequent primary pacing indication was complete heart block in 24 (44%). The median RV pacing burden was 45.4 (interquartile range [IQR] 3.5-97.0). On echocardiogram performed 8.9 months (IQR 4.5-14.5) after implant, there was no change in the average severity of tricuspid regurgitation (mean change 0.07 & PLUSMN; 1.15, p = .64) from pre-procedure echocardiogram. We observed a decrease in the average left ventricular ejection fraction (LVEF) (52.3 & PLUSMN; 9.3 to 47.9 & PLUSMN; 12.1, p = .0019) and tricuspid annular plane systolic excursion (TAPSE) (1.8 & PLUSMN; 0.6 to 1.6 & PLUSMN; 0.4, p = .0437). Thirteen patients (24%) had absolute drop in LVEF of & GE;10%.ConclusionWe did not observe short term worsening valvular function in patients with leadless pacemakers. However, consistent with the pathophysiologic impact of RV pacing, leadless pacing was associated with a reduction in biventricular function. Among 54 patients who underwent transthoracic echocardiogram before and after leadless pacemaker implant, there was no change in average severity of tricuspid regurgitation. Leadless pacing was associated with a reduction in biventricular systolic function as assessed by LVEF (left ventricular function) and TAPSE (right ventricular function).LVEF, left ventricular ejection fraction; TAPSE, tricuspid annular plane systolic excursion; TR, tricuspid regurgitationimage
引用
收藏
页码:2233 / 2242
页数:10
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