Neurophysiological, histological, and behavioral characterization of animal models of distraction spinal cord injury: a systematic review

被引：5

作者：

Han, Bo ^{[1
]}

Liang, Weishi ^{[1
]}

Hai, Yong ^{[1
]}

Sun, Duan ^{[1
]}

Ding, Hongtao ^{[1
]}

Yang, Yihan ^{[1
]}

Yin, Peng ^{[1
]}

机构：

[1] Capital Med Univ, Beijing Chao Yang Hosp, Dept Orthoped, Beijing, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2024年 / 19卷 / 03期

基金：

中国国家自然科学基金;

关键词：

animal models; behavior; distraction; heterogeneity; histology; mechanism; neurophysiology; spinal cord injury; systematic review; tension; VERTEBRAL COLUMN DISTRACTION; STRESS-INDUCED APOPTOSIS; IMPROVES RECOVERY; STEM-CELLS; RAT; DISLOCATION; CONTUSION; MECHANISMS; TRANSPLANTATION; MANAGEMENT;

D O I：

10.4103/1673-5374.380871

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Distraction spinal cord injury is caused by some degree of distraction or longitudinal tension on the spinal cord and commonly occurs in patients who undergo corrective operation for severe spinal deformity. With the increased degree and duration of distraction, spinal cord injuries become more serious in terms of their neurophysiology, histology, and behavior. Very few studies have been published on the specific characteristics of distraction spinal cord injury. In this study, we systematically review 22 related studies involving animal models of distraction spinal cord injury, focusing particularly on the neurophysiological, histological, and behavioral characteristics of this disease. In addition, we summarize the mechanisms underlying primary and secondary injuries caused by distraction spinal cord injury and clarify the effects of different degrees and durations of distraction on the primary injuries associated with spinal cord injury. We provide new concepts for the establishment of a model of distraction spinal cord injury and related basic research, and provide reference guidelines for the clinical diagnosis and treatment of this disease.

引用

页码：563 / 570

页数：8

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